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Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents
Theranostic radioisotope pairs such as Gallium-68 (68Ga) for Positron Emission Tomography (PET) and Lutetium-177 (177Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer. The present work aims to demonstrate the ability of condensed...
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| Published in: | Nanomaterials (Basel, Switzerland) Switzerland), 2022-07, Vol.12 (14), p.2490 |
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| creator | Salvanou, Evangelia-Alexandra Kolokithas-Ntoukas, Argiris Liolios, Christos Xanthopoulos, Stavros Paravatou-Petsotas, Maria Tsoukalas, Charalampos Avgoustakis, Konstantinos Bouziotis, Penelope |
| description | Theranostic radioisotope pairs such as Gallium-68 (68Ga) for Positron Emission Tomography (PET) and Lutetium-177 (177Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer. The present work aims to demonstrate the ability of condensed colloidal nanocrystal clusters (co-CNCs) comprised of iron oxide nanoparticles, coated with alginic acid (MA) and stabilized by a layer of polyethylene glycol (MAPEG) to be directly radiolabeled with 68Ga and its therapeutic analog 177Lu. 68Ga/177Lu- MA and MAPEG were investigated for their in vitro stability. The biocompatibility of the non-radiolabeled nanoparticles, as well as the cytotoxicity of MA, MAPEG, and [177Lu]Lu-MAPEG were assessed on 4T1 cells. Finally, the ex vivo biodistribution of the 68Ga-labeled NPs as well as [177Lu]Lu-MAPEG was investigated in normal mice. Radiolabeling with both radioisotopes took place via a simple and direct labelling method without further purification. Hemocompatibility was verified for both NPs, while MTT studies demonstrated the non-cytotoxic profile of the nanocarriers and the dose-dependent toxicity for [177Lu]Lu-MAPEG. The radiolabeled nanoparticles mainly accumulated in RES organs. Based on our preliminary results, we conclude that MAPEG could be further investigated as a theranostic agent for PET diagnosis and therapy of cancer. |
| doi_str_mv | 10.3390/nano12142490 |
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The present work aims to demonstrate the ability of condensed colloidal nanocrystal clusters (co-CNCs) comprised of iron oxide nanoparticles, coated with alginic acid (MA) and stabilized by a layer of polyethylene glycol (MAPEG) to be directly radiolabeled with 68Ga and its therapeutic analog 177Lu. 68Ga/177Lu- MA and MAPEG were investigated for their in vitro stability. The biocompatibility of the non-radiolabeled nanoparticles, as well as the cytotoxicity of MA, MAPEG, and [177Lu]Lu-MAPEG were assessed on 4T1 cells. Finally, the ex vivo biodistribution of the 68Ga-labeled NPs as well as [177Lu]Lu-MAPEG was investigated in normal mice. Radiolabeling with both radioisotopes took place via a simple and direct labelling method without further purification. Hemocompatibility was verified for both NPs, while MTT studies demonstrated the non-cytotoxic profile of the nanocarriers and the dose-dependent toxicity for [177Lu]Lu-MAPEG. The radiolabeled nanoparticles mainly accumulated in RES organs. Based on our preliminary results, we conclude that MAPEG could be further investigated as a theranostic agent for PET diagnosis and therapy of cancer.</description><identifier>ISSN: 2079-4991</identifier><identifier>EISSN: 2079-4991</identifier><identifier>DOI: 10.3390/nano12142490</identifier><identifier>PMID: 35889715</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Alginic acid ; Animals ; Atoms & subatomic particles ; Biocompatibility ; Biodistribution ; Cancer ; Cancer therapies ; Charged particles ; Chromatography ; condensed clusters ; Cytotoxicity ; Experiments ; Gallium ; Gallium isotopes ; Gallium-68 ; Gamma rays ; Iodine ; iron oxide nanoparticles ; Iron oxides ; Labeling ; Lutetium ; Lutetium isotopes ; Lutetium-177 ; Magnetic resonance imaging ; MTT ; Nanocrystals ; Nanoparticles ; Organs ; Polyethylene glycol ; Polyethylene terephthalate ; Positron emission tomography ; Radioisotopes ; radiolabeling ; Radiolabelling ; Tomography ; Toxicity</subject><ispartof>Nanomaterials (Basel, Switzerland), 2022-07, Vol.12 (14), p.2490</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3000-f460c68b911d0fa83e752f49e5782e6e53b697da1084d6112e77893a4ef90f3c3</citedby><cites>FETCH-LOGICAL-c3000-f460c68b911d0fa83e752f49e5782e6e53b697da1084d6112e77893a4ef90f3c3</cites><orcidid>0000-0001-6778-2201 ; 0000-0002-1909-6212 ; 0000-0003-1090-3492 ; 0000-0001-8592-0380</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2694033506/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2694033506?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><creatorcontrib>Salvanou, Evangelia-Alexandra</creatorcontrib><creatorcontrib>Kolokithas-Ntoukas, Argiris</creatorcontrib><creatorcontrib>Liolios, Christos</creatorcontrib><creatorcontrib>Xanthopoulos, Stavros</creatorcontrib><creatorcontrib>Paravatou-Petsotas, Maria</creatorcontrib><creatorcontrib>Tsoukalas, Charalampos</creatorcontrib><creatorcontrib>Avgoustakis, Konstantinos</creatorcontrib><creatorcontrib>Bouziotis, Penelope</creatorcontrib><title>Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents</title><title>Nanomaterials (Basel, Switzerland)</title><description>Theranostic radioisotope pairs such as Gallium-68 (68Ga) for Positron Emission Tomography (PET) and Lutetium-177 (177Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer. The present work aims to demonstrate the ability of condensed colloidal nanocrystal clusters (co-CNCs) comprised of iron oxide nanoparticles, coated with alginic acid (MA) and stabilized by a layer of polyethylene glycol (MAPEG) to be directly radiolabeled with 68Ga and its therapeutic analog 177Lu. 68Ga/177Lu- MA and MAPEG were investigated for their in vitro stability. The biocompatibility of the non-radiolabeled nanoparticles, as well as the cytotoxicity of MA, MAPEG, and [177Lu]Lu-MAPEG were assessed on 4T1 cells. Finally, the ex vivo biodistribution of the 68Ga-labeled NPs as well as [177Lu]Lu-MAPEG was investigated in normal mice. Radiolabeling with both radioisotopes took place via a simple and direct labelling method without further purification. Hemocompatibility was verified for both NPs, while MTT studies demonstrated the non-cytotoxic profile of the nanocarriers and the dose-dependent toxicity for [177Lu]Lu-MAPEG. The radiolabeled nanoparticles mainly accumulated in RES organs. Based on our preliminary results, we conclude that MAPEG could be further investigated as a theranostic agent for PET diagnosis and therapy of cancer.</description><subject>Alginic acid</subject><subject>Animals</subject><subject>Atoms & subatomic particles</subject><subject>Biocompatibility</subject><subject>Biodistribution</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Charged particles</subject><subject>Chromatography</subject><subject>condensed clusters</subject><subject>Cytotoxicity</subject><subject>Experiments</subject><subject>Gallium</subject><subject>Gallium isotopes</subject><subject>Gallium-68</subject><subject>Gamma rays</subject><subject>Iodine</subject><subject>iron oxide nanoparticles</subject><subject>Iron oxides</subject><subject>Labeling</subject><subject>Lutetium</subject><subject>Lutetium isotopes</subject><subject>Lutetium-177</subject><subject>Magnetic resonance imaging</subject><subject>MTT</subject><subject>Nanocrystals</subject><subject>Nanoparticles</subject><subject>Organs</subject><subject>Polyethylene glycol</subject><subject>Polyethylene terephthalate</subject><subject>Positron emission 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Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents</title><author>Salvanou, Evangelia-Alexandra ; Kolokithas-Ntoukas, Argiris ; Liolios, Christos ; Xanthopoulos, Stavros ; Paravatou-Petsotas, Maria ; Tsoukalas, Charalampos ; Avgoustakis, Konstantinos ; Bouziotis, Penelope</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3000-f460c68b911d0fa83e752f49e5782e6e53b697da1084d6112e77893a4ef90f3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alginic acid</topic><topic>Animals</topic><topic>Atoms & subatomic particles</topic><topic>Biocompatibility</topic><topic>Biodistribution</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Charged particles</topic><topic>Chromatography</topic><topic>condensed clusters</topic><topic>Cytotoxicity</topic><topic>Experiments</topic><topic>Gallium</topic><topic>Gallium 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Emission Tomography (PET) and Lutetium-177 (177Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer. The present work aims to demonstrate the ability of condensed colloidal nanocrystal clusters (co-CNCs) comprised of iron oxide nanoparticles, coated with alginic acid (MA) and stabilized by a layer of polyethylene glycol (MAPEG) to be directly radiolabeled with 68Ga and its therapeutic analog 177Lu. 68Ga/177Lu- MA and MAPEG were investigated for their in vitro stability. The biocompatibility of the non-radiolabeled nanoparticles, as well as the cytotoxicity of MA, MAPEG, and [177Lu]Lu-MAPEG were assessed on 4T1 cells. Finally, the ex vivo biodistribution of the 68Ga-labeled NPs as well as [177Lu]Lu-MAPEG was investigated in normal mice. Radiolabeling with both radioisotopes took place via a simple and direct labelling method without further purification. Hemocompatibility was verified for both NPs, while MTT studies demonstrated the non-cytotoxic profile of the nanocarriers and the dose-dependent toxicity for [177Lu]Lu-MAPEG. 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| subjects | Alginic acid Animals Atoms & subatomic particles Biocompatibility Biodistribution Cancer Cancer therapies Charged particles Chromatography condensed clusters Cytotoxicity Experiments Gallium Gallium isotopes Gallium-68 Gamma rays Iodine iron oxide nanoparticles Iron oxides Labeling Lutetium Lutetium isotopes Lutetium-177 Magnetic resonance imaging MTT Nanocrystals Nanoparticles Organs Polyethylene glycol Polyethylene terephthalate Positron emission tomography Radioisotopes radiolabeling Radiolabelling Tomography Toxicity |
| title | Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents |
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