Competitive Performance of Carbon "Quantum" Dots in Optical Bioimaging

Carbon-based "quantum" dots or carbon dots are surface-functionalized small carbon nanoparticles. For bright fluorescence emissions, the carbon nanoparticles may be surface-doped with an inorganic salt and then the same organic functionalization. In this study, carbon dots without and with...

Full description

Saved in:
Bibliographic Details
Published in:Theranostics 2012-01, Vol.2 (1), p.295-301
Main Author: Li Cao, Sheng-Tao Yang, Xin Wang, Pengju G. Luo, Jia-Hui Liu, Sushant Sahu, Yamin Liu, Ya-Ping Sun
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Carbon-based "quantum" dots or carbon dots are surface-functionalized small carbon nanoparticles. For bright fluorescence emissions, the carbon nanoparticles may be surface-doped with an inorganic salt and then the same organic functionalization. In this study, carbon dots without and with the ZnS doping were prepared, followed by gel-column fractionation to harvest dots of 40% and 60% in fluorescence quantum yields, respectively. These highly fluorescent carbon dots were evaluated for optical imaging in mice, from which bright fluorescence images were obtained. Of particular interest was the observed competitive performance of the carbon dots in vivo to that of the well-established CdSe/ZnS QDs. The results suggest that carbon dots may be further developed into a new class of high-performance yet nontoxic contrast agents for optical bioimaging.
ISSN:1838-7640
1838-7640