Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography

The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency...

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Published in:Scientific reports 2021-09, Vol.11 (1), p.19386-11, Article 19386
Main Authors: Garteiser, Philippe, Pagé, Gwenaël, d’Assignies, Gaspard, Leitao, Helena S., Vilgrain, Valérie, Sinkus, Ralph, Van Beers, Bernard E.
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Language:English
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631/1647/245/1628
639/301/930/2735
692/4020/4021
692/53/2421
Adult
Aged
Bioengineering
Biomechanics
Cirrhosis
Elasticity Imaging Techniques - methods
Engineering Sciences
Female
Fibrosis
Hepatitis
Hepatitis B
Hepatitis B, Chronic - diagnostic imaging
Hepatitis C, Chronic - diagnostic imaging
Human health and pathology
Humanities and Social Sciences
Humans
Hépatology and Gastroenterology
Imaging
Imaging, Three-Dimensional - methods
Infectious diseases
Inflammation
Life Sciences
Liver
Liver cirrhosis
Male
Mechanics
Middle Aged
multidisciplinary
Multiple regression analysis
Regression analysis
Science
Science (multidisciplinary)
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description The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56 Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fibrosis was the only determinant of the storage, loss and shear moduli. The multifrequency dispersion coefficient had the largest AUC for necro-inflammatory activity A ≥ 2 [0.84 (0.71–0.93) vs. storage modulus AUC: 0.65 (0.50–0.79), p  = 0.03], whereas the storage modulus had the largest AUC for fibrosis F ≥ 2 [AUC (95% confidence intervals) 0.91 (0.79–0.98)] and cirrhosis F4 [0.97 (0.88–1.00)]. The measurement of the multifrequency dispersion coefficient at three-dimensional MR elastography has the potential to grade liver necro-inflammation in patients with chronic vial hepatitis.
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Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56 Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fibrosis was the only determinant of the storage, loss and shear moduli. 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subjects 631/1647/245/1628
639/301/930/2735
692/4020/4021
692/53/2421
Adult
Aged
Bioengineering
Biomechanics
Cirrhosis
Elasticity Imaging Techniques - methods
Engineering Sciences
Female
Fibrosis
Hepatitis
Hepatitis B
Hepatitis B, Chronic - diagnostic imaging
Hepatitis C, Chronic - diagnostic imaging
Human health and pathology
Humanities and Social Sciences
Humans
Hépatology and Gastroenterology
Imaging
Imaging, Three-Dimensional - methods
Infectious diseases
Inflammation
Life Sciences
Liver
Liver cirrhosis
Male
Mechanics
Middle Aged
multidisciplinary
Multiple regression analysis
Regression analysis
Science
Science (multidisciplinary)
title Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography
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