Characterization of Magnesium-Polylactic Acid Films Casted on Different Substrates and Doped with Diverse Amounts of CTAB

Polylactic acid (PLA) is a good candidate for the manufacture of polymeric biodegradable biomaterials. The inclusion of metallic particles and surfactants solves its mechanical limitations and improves its wettability, respectively. In this work, cetyltrimethylammonium bromide (CTAB) and magnesium p...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-08, Vol.26 (16), p.4811
Main Authors: Hierro-Oliva, Margarita, Luque-Agudo, Verónica, Gallardo-Moreno, Amparo M., González-Martín, M. Luisa
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Biodegradation
Biomaterials
Biomedical materials
Cell adhesion
Composite materials
Contact angle
Exclusion zones
Glass substrates
Magnesium
Mechanical properties
Metal particles
Orthopedics
Pollutants
Polylactic acid
Polymers
Silicones
Substrates
surface characterization
Surfactants
Transplants & implants
Wettability
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Summary:Polylactic acid (PLA) is a good candidate for the manufacture of polymeric biodegradable biomaterials. The inclusion of metallic particles and surfactants solves its mechanical limitations and improves its wettability, respectively. In this work, cetyltrimethylammonium bromide (CTAB) and magnesium particles have been incorporated into PLA films to evaluate the changes produced in the polymeric matrix cast on glass and silicone substrates. For this purpose, the surface of the films has been characterized by means of contact angle measurements and ToF-SIMS. Depth profiles and SEM images of the cross sections of the films have also been obtained to study their morphology. The results show that the CTAB in the polymer matrix with and without magnesium improves the wettability of the films, making them more suitable for cell adhesion. The higher the hydrophilicity, the higher the surfactant concentration. The depth profiles show, for the first time, that, depending on the surfactant concentration and the presence of Mg, there is a layer-like distribution near the surface where, in addition to the CTAB + PLA mixture, a surfactant exclusion zone can be seen. This new structure could be relevant in in vitro/in vivo situations when the degradation processes remove the film components in a sequential form.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26164811