Long-term survival following medical management of Aspergillus endocarditis with dissemination as a consequence of steroid therapy in severe COVID-19 pneumonia

A male in his 40's with no known comorbidities developed severe COVID-19 pneumonia and received a four-week course of methylprednisolone. The patient subsequently developed disseminated Aspergillus endocarditis, manifesting as multiple organ involvement including the heart, eyes, and brain. Des...

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Bibliographic Details
Published in:Medical mycology case reports 2024-03, Vol.43, p.100638, Article 100638
Main Authors: Kulirankal, Kiran G., Mary, Ann, Moni, Merlin, Pillai, Gopal S., Sathyapalan, Dipu T.
Format: Article
Language:English
Subjects:
Aspergillus fumigatus
Case Report
Covid pneumonia
COVID-19
Disseminated Aspergillus
Fungal endocarditis
Infectious diseases
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Summary:A male in his 40's with no known comorbidities developed severe COVID-19 pneumonia and received a four-week course of methylprednisolone. The patient subsequently developed disseminated Aspergillus endocarditis, manifesting as multiple organ involvement including the heart, eyes, and brain. Despite the poor prognosis generally associated with fungal endocarditis, the patient survived following aggressive medical management with a combination of liposomal amphotericin b and voriconazole therapy and is now doing well for over two years and is off antifungal therapy for a year.
ISSN:2211-7539
2211-7539
DOI:10.1016/j.mmcr.2024.100638