Non-invasive brain stimulation for fatigue in post-acute sequelae of SARS-CoV-2 (PASC)

and purpose: Fatigue is among the most common persistent symptoms following post-acute sequelae of Sars-COV-2 infection (PASC). The current study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCS) associated with rehabilitation program...

Full description

Saved in:
Bibliographic Details
Published in:Brain stimulation 2023-01, Vol.16 (1), p.100-107
Main Authors: Santana, Kelly, França, Eduardo, Sato, João, Silva, Ana, Queiroz, Maria, de Farias, Julia, Rodrigues, Danniely, Souza, Iara, Ribeiro, Vanessa, Caparelli-Dáquer, Egas, Teixeira, Antonio L., Charvet, Leigh, Datta, Abhishek, Bikson, Marom, Andrade, Suellen
Format: Article
Language:English
Subjects:
Anxiety
Brain - physiology
COVID-19 - complications
Fatigue
Fatigue - etiology
Fatigue - therapy
High-Definition transcranial direct current stimulation
Humans
Non-invasive brain stimulation
Pain - etiology
Post-Acute COVID-19 Syndrome
Post-acute sequelae of Sars-COV-2
Quality of Life
Respiratory rehabilitation
SARS-CoV-2
Transcranial Direct Current Stimulation - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:and purpose: Fatigue is among the most common persistent symptoms following post-acute sequelae of Sars-COV-2 infection (PASC). The current study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCS) associated with rehabilitation program for the management of PASC-related fatigue. Seventy patients with PASC-related fatigue were randomized to receive 3 mA or sham HD-tDCS targeting the left primary motor cortex (M1) for 30 min paired with a rehabilitation program. Each patient underwent 10 sessions (2 sessions/week) over five weeks. Fatigue was measured as the primary outcome before and after the intervention using the Modified Fatigue Impact Scale (MFIS). Pain level, anxiety severity and quality of life were secondary outcomes assessed, respectively, through the McGill Questionnaire, Hamilton Anxiety Rating Scale (HAM-A) and WHOQOL. Active HD-tDCS resulted in significantly greater reduction in fatigue compared to sham HD-tDCS (mean group MFIS reduction of 22.11 points vs 10.34 points). Distinct effects of HD-tDCS were observed in fatigue domains with greater effect on cognitive (mean group difference 8.29 points; effect size 1.1; 95% CI 3.56–13.01; P 
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2023.01.1672