Role of Sulfur Compounds in Garlic as Potential Therapeutic Option for Inflammation and Oxidative Stress in Asthma

Asthma is a chronic inflammatory disease in the airways with a multifactorial origin but with inflammation and oxidative stress as related pathogenic mechanisms. Garlic ( ) is a nutraceutical with different biological properties due to sulfur-containing natural compounds. Studies have shown that sev...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.23 (24), p.15599
Main Authors: Sánchez-Gloria, José L, Rada, Karla M, Juárez-Rojas, Juan G, Sánchez-Lozada, Laura G, Rubio-Gayosso, Ivan, Sánchez-Muñoz, Fausto, Osorio-Alonso, Horacio
Format: Article
Language:English
Subjects:
Allergens
Allergies
Allium sativum
Antibiotics
Antioxidants
Antioxidants - pharmacology
Asthma
Asthma - drug therapy
Bacterial infections
Biological properties
Cardiovascular diseases
Chemical compounds
Chronic illnesses
Chronic obstructive pulmonary disease
Cytokines
Functional foods & nutraceuticals
Garlic
Health services
Humans
Immunoglobulins
Inflammation
Inflammation - drug therapy
Inflammatory diseases
Lung diseases
Medical prognosis
Nitric oxide
Oxidative Stress
Pathology
Pharmacology
Plant Extracts - pharmacology
Respiratory diseases
Review
Steroids
Streptococcus infections
Sulfur
Sulfur compounds
Sulfur Compounds - pharmacology
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Summary:Asthma is a chronic inflammatory disease in the airways with a multifactorial origin but with inflammation and oxidative stress as related pathogenic mechanisms. Garlic ( ) is a nutraceutical with different biological properties due to sulfur-containing natural compounds. Studies have shown that several compounds in garlic may have beneficial effects on cardiovascular diseases, including those related to the lungs. Therefore, it is possible to take advantage of the compounds from garlic as nutraceuticals for treating lung diseases. The objective of this article is to review the biological properties of the sulfur compounds present in garlic for the treatment of asthma, as well as the cellular mechanisms involved. Here, we discuss the potential therapeutic effects of garlic compounds in the modulation of inflammation and oxidative stress, as well as its antibiotic and antiviral activities for identifying and testing potential treatment options for asthma management.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232415599