Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

Cardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on...

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Bibliographic Details
Published in:Antioxidants 2022-06, Vol.11 (6), p.1175
Main Authors: Kong, Amanda Shen-Yee, Lai, Kok Song, Hee, Cheng-Wan, Loh, Jiun Yan, Lim, Swee Hua Erin, Sathiya, Maran
Format: Article
Language:English
Subjects:
Angina pectoris
Antioxidants
Biomarkers
cardiovascular
Cardiovascular disease
Cardiovascular diseases
Coronary vessels
Free radicals
Heart attacks
High density lipoprotein
Hypertension
Lipids
Mortality
Neutrophils
oxidant
Oxidants
Oxidative stress
Plasma
Reactive oxygen species
Review
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Summary:Cardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on biological targets such as lipids, proteins, and DNA. Since the existing clinical studies with antioxidants failed to provide relevant findings on CVD prediction, the focus has shifted towards recognition of oxidised targets as biomarkers to predict prognosis and response to accurate treatment. The identification of redox markers could help clinicians in providing risk stratification for CVD events beyond the traditional prognostic and diagnostic targets. This review will focus on how oxidant-related parameters can be applied as biomarkers for CVD based on recent clinical evidence.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11061175