Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study

• Published in: Scientific reports 2021-06, Vol.11 (1), p.11822-11822, Article 11822
• Main Authors: Papantoniou, Kyriaki, Castaño-Vinyals, Gemma, Espinosa, Ana, Turner, Michelle C., Martín-Sánchez, Vicente, Casabonne, Delphine, Aragonés, Nuria, Gómez-Acebo, Inés, Ardanaz, Eva, Jimenez-Moleon, Jose-Juan, Amiano, Pilar, Molina-Barceló, Ana, Alguacil, Juan, Fernández-Tardón, Guillermo, Huerta, José María, Hernández-Segura, Natalia, Perez-Gomez, Beatriz, Llorca, Javier, Vidán-Alli, Juana, Olmedo-Requena, Rocıo, Gil, Leire, Castañon-López, Carmen, Pollan, Marina, Kogevinas, Manolis, Moreno, Victor
• Format: Article
• Language: English
• Subjects: 631/67; 692/4020; 692/499; Circadian rhythms; Colorectal cancer; Colorectal carcinoma; Daytime; Etiology; Gastric cancer; Humanities and Social Sciences; multidisciplinary; Regression analysis; Risk factors; Science; Science (multidisciplinary); Sleep
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-91275-3

Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case–control study (2008–2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR ≥9 hours : 1.59; 95%CI 1.30–1.94) and gastric cancer (OR ≥9 hours : 1.95; 1.37–2.76); short sleep was associated with increased odds of gastric cancer (OR ≤5 hours : 1.32; 0.93–1.88). Frequent and long daytime naps increased the odds of colorectal (OR 6–7 naps/week, ≥30 min : 1.32; 1.14–1.54) and gastric cancer (OR 6–7 naps/week, ≥30 min : 1.56; 1.21–2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.