Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement

• Published in: Journal of the Formosan Medical Association 2017-09, Vol.116 (9), p.679-688
• Main Authors: Chen, Yuan-Chien, Shie, Ming-You, Wu, Yuan-Haw Andrew, Lee, Kai-Xing Alvin, Wei, Li-Ju, Shen, Yu-Fang
• Format: Article
• Language: English
• Subjects: Anti-inflammation; Anti-Inflammatory Agents - pharmacology; Bone cement; Calcium silicate; Cells, Cultured; Curcumin; Curcumin - chemistry; Curcumin - pharmacology; Humans; Interleukin-1 - biosynthesis; Materials Testing; Mesoporous; Porosity; Silicate Cement - chemistry; Tumor Necrosis Factor-alpha - biosynthesis
• ISSN: 0929-6646; 1876-0821
• DOI: 10.1016/j.jfma.2017.06.005

Calcium silicate (CS) cements have excellent bioactivity and can induce the bone-like apatite formation. They are good biomaterials for bone tissue engineering and bone regenerative medicine. However, they have degradability and the dissolved CS can cause the inflammatory response at the early post-implantation stage. The purpose of this study was to design and prepare the curcumin-loaded mesoporous CS (MesoCS/curcumin) cements as a strategy to reduce the inflammatory reaction after implantation. The MesoCS/curcumin cements were designed and prepared. The characteristics of MesoCS/curcumin specimens were examined by transmission electron microscopy (TEM), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Their physical properties, biocompatibility, and anti-inflammatory ability were also evaluated. The MesoCS/curcumin cements displayed excellent biocompatibility and physical properties. Their crystalline characterizations were very similar with MesoCS cements. After soaking in simulated body fluid, the bone-like apatite layer of the MesoCS/curcumin cements could be formed. In addition, it could inhibit the expression of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) after inflammation reaction induced by lipopolysaccharides and had good anti-inflammatory ability. Adding curcumin in MesoCS cements can reduce the inflammatory reaction, but does not affect the original biological activity and properties of MesoCS cements. It can provide a good strategy to inhibit the inflammatory reaction after implantation for bone tissue engineering and bone regenerative medicine.