Facile Green, Room-Temperature Synthesis of Gold Nanoparticles Using Combretum erythrophyllum Leaf Extract: Antibacterial and Cell Viability Studies against Normal and Cancerous Cells

We herein report a facile, green, cost-effective, plant-mediated synthesis of gold nanoparticles (AuNPs) for the first time using Combretum erythrophyllum (CE) plant leaves. The synthesis was conducted at room temperature using CE leaf extract serving as a reducing and capping agent. The as-synthesi...

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Bibliographic Details
Published in:Antibiotics (Basel) 2021-07, Vol.10 (8), p.893
Main Authors: Fanoro, Olufunto T., Parani, Sundararajan, Maluleke, Rodney, Lebepe, Thabang C., Varghese, Jose R., Mavumengwana, Vuyo, Oluwafemi, Oluwatobi S.
Format: Article
Language:English
Subjects:
antibacterial
Antibacterial activity
Bacteria
Biosynthesis
Cancer
Cell viability
Cervix
Coliforms
Color
Combretum
Combretum erythrophyllum
Cytotoxicity
E coli
Flavonoids
Gold
gold nanoparticles
Gram-negative bacteria
Klebsiella
Klebsiella pneumoniae
Leaves
Lung cancer
Nanoparticles
Particle size
Phytochemicals
Plant extracts
Plants
Room temperature
Spectrum analysis
Staphylococcus aureus
Synthesis
Tumor cell lines
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Summary:We herein report a facile, green, cost-effective, plant-mediated synthesis of gold nanoparticles (AuNPs) for the first time using Combretum erythrophyllum (CE) plant leaves. The synthesis was conducted at room temperature using CE leaf extract serving as a reducing and capping agent. The as-synthesized AuNPs were found to be crystalline, well dispersed, and spherical in shape with an average diameter of 13.20 nm and an excellent stability of over 60 days. The AuNPs showed broad-spectrum antibacterial activities against both pathogenic Gram-positive (Staphylococcus epidermidis (ATCC14990), Staphylococcus aureus (ATCC 25923), Mycobacterium smegmatis (MC 215)) and Gram-negative bacteria (Proteus mirabilis (ATCC 7002), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 13822), Klebsiella oxytoca (ATCC 8724)), with a minimum inhibition concentration of 62.5 µg/mL. In addition, the as-synthesized AuNPs were highly stable with exceptional cell viability towards normal cells (BHK- 21) and cancerous cancer cell lines (cervical and lung cancer).
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10080893