Mutations in Non–Small Cell Lung Cancer: Clinicopathologic Features and Prognostic Implications

Introduction: The associations between the clinical characteristics of non–small cell lung cancer (NSCLC) and mutations in telomerase reverse transcriptase ( TERT ) gene remain unclear. In this study, we used next-generation sequencing (NGS) to investigate the incidence rate and clinical correlates...

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Published in:Clinical Medicine Insights. Oncology 2023-06, Vol.17
Main Authors: Liu Yang, Meng Wang, Na Li, Lu-Da Yan, Wen Zhou, Zhi-Qiong Yu, Xiao-Chun Peng, Jun Cai, Yong-Hua Yang
Format: Article
Language:English
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Summary:Introduction: The associations between the clinical characteristics of non–small cell lung cancer (NSCLC) and mutations in telomerase reverse transcriptase ( TERT ) gene remain unclear. In this study, we used next-generation sequencing (NGS) to investigate the incidence rate and clinical correlates of TERT mutations in patients with NSCLC. Methods: In total, 283 tumor samples from patients with NSCLC were tested using an NGS panel from September 2017 to May 2020. The genetic testing results and clinical data of all patients were collected. Results: TERT mutations were found in 30 patients, which were significantly associated with age, smoking history, sex, and metastasis ( P  
ISSN:1179-5549
DOI:10.1177/11795549221140781