Visible Pulsed Laser-Assisted Selective Killing of Cancer Cells with PVP-Capped Plasmonic Gold Nanostars

A new generation of nanoscale photosensitizer agents has improved photothermal capabilities, which has increased the impact of photothermal treatments (PTTs) in cancer therapy. Gold nanostars (GNS) are promising for more efficient and less invasive PTTs than gold nanoparticles. However, the combinat...

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Bibliographic Details
Published in:Micromachines (Basel) 2023-05, Vol.14 (6), p.1173
Main Authors: Mishra, Aniket, Inaam, Rafia, Okamoto, Shunya, Shibata, Takayuki, Santra, Tuhin Subhra, Nagai, Moeto
Format: Article
Language:English
Subjects:
Biocompatibility
Cancer
Cancer cells
Cancer therapies
Care and treatment
Cell death
Efficiency
Electromagnetism
Experiments
Gold
Health aspects
Irradiation
Laser applications
Lasers
less invasive
Morphology
Nanoparticles
nanosecond pulse laser
Nanosecond pulses
Penicillin
Photodynamic therapy
photothermal treatment
Polyvinylpyrrolidone
Pulsed lasers
PVP capped gold nanostars
Spectrum analysis
Temperature effects
Tumors
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Summary:A new generation of nanoscale photosensitizer agents has improved photothermal capabilities, which has increased the impact of photothermal treatments (PTTs) in cancer therapy. Gold nanostars (GNS) are promising for more efficient and less invasive PTTs than gold nanoparticles. However, the combination of GNS and visible pulsed lasers remains unexplored. This article reports the use of a 532 nm nanosecond pulse laser and polyvinylpyrrolidone (PVP)-capped GNS to kill cancer cells with location-specific exposure. Biocompatible GNS were synthesized via a simple method and were characterized under FESEM, UV-visible spectroscopy, XRD analysis, and particle size analysis. GNS were incubated over a layer of cancer cells that were grown in a glass Petri dish. A nanosecond pulsed laser was irradiated on the cell layer, and cell death was verified via propidium iodide (PI) staining. We assessed the effectiveness of single-pulse spot irradiation and multiple-pulse laser scanning irradiation in inducing cell death. Since the site of cell killing can be accurately chosen with a nanosecond pulse laser, this technique will help minimize damage to the cells around the target cells.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi14061173