Circulating liver function markers and the risk of COPD in the UK Biobank

To investigate the associations of circulating liver function marker levels with the risk of chronic obstructive pulmonary disease (COPD). We leveraged the data of 372,056 participants from the UK Biobank between 2006 and 2010. The assessed circulating liver function markers included alanine aminotr...

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Published in:Frontiers in endocrinology (Lausanne) 2023-03, Vol.14, p.1121900-1121900
Main Authors: Du, Wencong, Guan, Haoyu, Wan, Xinglin, Zhu, Zheng, Yu, Hao, Luo, Pengfei, Chen, Lulu, Su, Jian, Lu, Yan, Hang, Dong, Tao, Ran, Wu, Ming, Zhou, Jinyi, Fan, Xikang
Format: Article
Language:English
Subjects:
Albumins
Alkaline Phosphatase - metabolism
Bilirubin
Biological Specimen Banks
chronic obstructive pulmonary disease
Endocrinology
gamma-Glutamyltransferase
Humans
Liver - metabolism
liver function
Liver Function Tests
liver-lung axis
prospective cohort study
serum biomarker
State Medicine
United Kingdom - epidemiology
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Summary:To investigate the associations of circulating liver function marker levels with the risk of chronic obstructive pulmonary disease (COPD). We leveraged the data of 372,056 participants from the UK Biobank between 2006 and 2010. The assessed circulating liver function markers included alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBIL), albumin (ALB), and total protein (TP). Incident COPD was identified through linkage to the National Health Service registries. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During a median follow-up period of 12.3 (interquartile range:11.4-13.2) years, we documented 10,001 newly diagnosed COPD cases. Lower levels of ALT, TBIL, ALB, and TP and higher levels of GGT and ALP were nonlinearly associated with elevated COPD risk. The HR (95% CI) for decile 10 vs. 1 was 0.92 (0.84-1.01) for ALT, 0.82 (0.75-0.89) for TBIL, 0.74 (0.67-0.81) for ALB, 0.96 (0.88-1.04) for TP, 1.45 (1.31-1.62) for GGT, and 1.31 (1.19-1.45) for ALP. Restricted cubic spline analyses suggested a U-shaped relationship between AST levels and COPD risk ( for nonlinearity
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1121900