Does the Heart Want What It Wants? A Case for Self-Adapting, Mechano-Sensitive Therapies After Infarction

There is a critical need for interventions to control the development and remodeling of scar tissue after myocardial infarction. A significant hurdle to fibrosis-related therapy is presented by the complex spatial needs of the infarcted ventricle, namely that collagenous buildup is beneficial in the...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2021-09, Vol.8, p.705100-705100
Main Authors: Richardson, William J., Rogers, Jesse D., Spinale, Francis G.
Format: Article
Language:English
Subjects:
cardiac fibroblast
Cardiovascular Medicine
fibrosis
heterogeneity
mechanobiology
mechanotransduction
myocardial infarction
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Summary:There is a critical need for interventions to control the development and remodeling of scar tissue after myocardial infarction. A significant hurdle to fibrosis-related therapy is presented by the complex spatial needs of the infarcted ventricle, namely that collagenous buildup is beneficial in the ischemic zone but detrimental in the border and remote zones. As a new, alternative approach, we present a case to develop self-adapting, mechano-sensitive drug targets in order to leverage local, microenvironmental mechanics to modulate a therapy's pharmacologic effect. Such approaches could provide self-tuning control to either promote fibrosis or reduce fibrosis only when and where it is beneficial to do so.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2021.705100