Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice

PURPOSE: To evaluate the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.METHODS:The anti-inflammatory effect of alcoholic extracts of green tea (AE) was evaluated in a cell migration assay with four groups of six Swiss mice receiving 0.07g/Kg or 0.14g/Kg EA (treatme...

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Published in:Acta cirúrgica brasileira 2015-04, Vol.30 (4), p.242-246
Main Authors: Mota, Matheus Alves de Lima, Landim, José Saul Peixoto, Targino, Thiago Sousa Silva, Silva, Silvia Fernandes Ribeiro da, Silva, Sônia Leite da, Pereira, Márcio Roberto Pinho
Format: Article
Language:English
Subjects:
Analgesics
Anti-inflammatory Agents
Camellia sinensis
Catechin
Mice
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Summary:PURPOSE: To evaluate the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.METHODS:The anti-inflammatory effect of alcoholic extracts of green tea (AE) was evaluated in a cell migration assay with four groups of six Swiss mice receiving 0.07g/Kg or 0.14g/Kg EA (treatment groups), saline (negative control) or 10mg/Kg indomethacin (positive control) by gavage. One hour later 300 µg carrageen an was administered intraperitoneally or subcutaneously. The analgesic effect was evaluated using four groups of six animals receiving 0.07g/Kg or 0.14g/Kg EA, saline or 10mg/Kg indomethacin subcutaneously, followed 30 minutes later by 1% acetic acid.RESULTS: When administered subcutaneously at either dose (0.07g/Kg and 0.14g/Kg), AE inhibited carrageenan-induced cell migration (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-865020150040000002