NSAID associated bilateral renal infarctions: a case report

Renal infarctions (RIs) are caused by interruptions in the renal arterial blood flow. RIs are generally considered to be rare, however we present the case of a 37 year old woman whose renal infarction was likely due to the vasoconstrictive effects of non-steroidal anti-inflammatory drugs. Although h...

Full description

Saved in:
Bibliographic Details
Published in:International journal of nephrology and renovascular disease 2019-08, Vol.12, p.177-181
Main Authors: Jeon, Yejoo, Lis, Jonathan B, Chang, William G
Format: Article
Language:English
Subjects:
Abdomen
Anti-inflammatory agents
Blood flow
Case Report
Case reports
Health risk assessment
Infarction
Inflammation
Kidneys
Medical schools
Nonsteroidal anti-inflammatory agents
Nonsteroidal anti-inflammatory drugs
Perfusion
Prostaglandins
Renal artery obstruction
renovascular acute kidney injury vasoconstriction prostaglandins
Steroidal anti-inflammatory agents
Tromethamine
Vasoconstriction
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Renal infarctions (RIs) are caused by interruptions in the renal arterial blood flow. RIs are generally considered to be rare, however we present the case of a 37 year old woman whose renal infarction was likely due to the vasoconstrictive effects of non-steroidal anti-inflammatory drugs. Although high-dose non-steroidal anti-inflammatory drugs (NSAIDs) are known to cause a decrease in renal perfusion, they have not been accepted as causative agents in renal infarction. Theoretically, patients in prostaglandin dependent states should be more vulnerable to renovascular vasoconstriction and resulting hypoperfusion in the presence of NSAIDs. Given the high prevalence of NSAID use, we suspect that this mechanism of renal injury may be more prevalent than previously thought.
ISSN:1178-7058
1178-7058
DOI:10.2147/IJNRD.S212010