P53/NANOG balance; the leading switch between poorly to well differentiated status in liver cancer cells

Enforcing a well-differentiated state on cells requires tumor suppressor p53 activation as a key player in apoptosis induction and well differentiation. In addition, recent investigations showed a significant correlation between poorly differentiated status and higher expression of NANOG. Inducing t...

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Bibliographic Details
Published in:Frontiers in oncology 2024, Vol.14, p.1377761
Main Authors: Ranjbar-Niavol, Fazeleh, Rezaei, Niloufar, Zhao, Ying, Mirzaei, Hamed, Hassan, Moustapha, Vosough, Massoud
Format: Article
Language:English
Subjects:
cancer
hepatocellular carcinoma
Medicin och hälsovetenskap
molecular mechanism
NANOG
Oncology
p53
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Summary:Enforcing a well-differentiated state on cells requires tumor suppressor p53 activation as a key player in apoptosis induction and well differentiation. In addition, recent investigations showed a significant correlation between poorly differentiated status and higher expression of NANOG. Inducing the expression of NANOG and decreasing p53 level switch the status of liver cancer cells from well differentiated to poorly status. In this review, we highlighted p53 and NANOG cross-talk in hepatocellular carcinoma (HCC) which is regulated through mitophagy and makes it a novel molecular target to attenuate cancerous phenotype in the management of this tumor.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1377761