Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility

Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-r...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-08, Vol.24 (16), p.12558
Main Authors: Sánchez-Jasso, Diego Eduardo, López-Guzmán, Sergio Federico, Bermúdez-Cruz, Rosa Maria, Oviedo, Norma
Format: Article
Language:English
Subjects:
CREM
CREM isoforms
Cyclic adenylic acid
Fertility
Gene expression
gene regulation
Genes
Genomes
Infertility
Kinases
male fertility
Males
Motility
Phosphorylation
Proteins
Puberty
Review
Sperm
Spermatogenesis
Testosterone
Transcription factors
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Summary:Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-response element modulator (CREM) is a key modulator that triggers the differentiation of the germ cell into the spermatozoon through the modification of gene expression. CREM has multiple repressor and activator isoforms whose expression is tissue-cell-type specific and tightly regulated by various factors at the transcriptional, post-transcriptional and post-translational level. The activator isoform CREMτ controls the expression of several relevant genes in post-meiotic stages of spermatogenesis. In addition, exposure to xenobiotics negatively affects CREMτ expression, which is linked to male infertility. On the other hand, antioxidants could have a positive effect on CREMτ expression and improve sperm parameters in idiopathically infertile men. Therefore, CREM expression could be used as a biomarker to detect and even counteract male infertility. This review examines the importance of CREM as a transcription factor for sperm production and its relevance in male fertility, infertility and the response to environmental xenobiotics that may affect CREMτ expression and the downstream regulation that alters male fertility. Also, some health disorders in which CREM expression is altered are discussed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241612558