Antimicrobial Films Based on Nanocomposites of Chitosan/Poly(vinyl alcohol)/Graphene Oxide for Biomedical Applications

Today, tissue regeneration is one of the greatest challenges in the field of medicine, since it represents hope after accidents or illnesses. Tissue engineering is the science based on improving or restoring tissues and organs. In this work, five formulations of chitosan/poly(vinyl alcohol)/graphene...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2019-03, Vol.9 (3), p.109
Main Authors: Ruiz, Sebastián, Tamayo, Julián Andrés, Ospina, Johannes Delgado, Navia Porras, Diana Paola, Valencia Zapata, Mayra Eliana, Hernandez, José Herminsul Mina, Valencia, Carlos Humberto, Zuluaga, Fabio, Grande Tovar, Carlos David
Format: Article
Language:English
Subjects:
Antibacterial activity
Antimicrobial agents
Biodegradability
biodegradable films
Biodegradation
Chitosan
Gram-positive bacteria
Graphene
graphene oxide
Graphite
Inoculum
Molecular weight
Nanocomposites
poly(vinyl alcohol)
Polymers
Polyvinyl alcohol
Scanning electron microscopy
Spectrum analysis
Tissue engineering
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Summary:Today, tissue regeneration is one of the greatest challenges in the field of medicine, since it represents hope after accidents or illnesses. Tissue engineering is the science based on improving or restoring tissues and organs. In this work, five formulations of chitosan/poly(vinyl alcohol)/graphene oxide (CS/PVA/GO) nanocomposites were studied for the development of biodegradable films with potential biomedical applications. The characterization of the films consisted of Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The antibacterial activity was evaluated in vitro against Gram-positive bacteria and and Gram-negative spp. and , by contact of the film above inoculum bacterial in Müeller⁻Hinton agar. On the other hand, in vivo tests in which the material implanted in the subcutaneous tissue of Wistar rats demonstrated that the formulation CS/PVA/GO (14.25:85:0.75) was the best antibacterial film with adequate degradation in vivo. All together, these results indicate the potential of the films using nanocomposites of CS/PVA/GO in tissue engineering and cell regeneration.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom9030109