A self‐adhesive microneedle patch with drug loading capability through swelling effect

Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug‐loading via swelling effect of a...

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Bibliographic Details
Published in:Bioengineering & translational medicine 2020-05, Vol.5 (2), p.e10157-n/a
Main Authors: Chew, Sharon W. T., Shah, Ankur H., Zheng, Mengjia, Chang, Hao, Wiraja, Christian, Steele, Terry W. J., Xu, Chenjie
Format: Article
Language:English
Subjects:
Adhesives
Aqueous solutions
bioadhesive
dendrimer
Drug delivery systems
Drugs
Hyaluronic acid
Hydrogels
microneedles
Needles
Polymers
Research Report
Research Reports
self‐adhesive
Swelling
transdermal drug delivery
Transdermal medication
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Summary:Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug‐loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post‐fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm−2. Additional post‐fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10157