LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

Hair follicle stem cells are key for driving growth and homeostasis of the hair follicle niche, have remarkable regenerative capacity throughout hair cycling, and display fate plasticity during cutaneous wound healing. Due to the need for a transgenic reporter, essentially all observations related t...

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Bibliographic Details
Published in:Scientific reports 2022-06, Vol.12 (1), p.9104-9104, Article 9104
Main Authors: Polkoff, Kathryn M., Gupta, Nithin K., Green, Adrian J., Murphy, Yanet, Chung, Jaewook, Gleason, Katherine L., Simpson, Sean G., Walker, Derek M., Collins, Bruce, Piedrahita, Jorge A.
Format: Article
Language:English
Subjects:
631/208/721
631/532/2118
631/532/2438
Animals
Animals, Genetically Modified
Biomarkers - metabolism
Follicles
Gene expression
Hair
Hair Follicle - metabolism
Homeostasis
Humanities and Social Sciences
Humans
Morphogenesis
multidisciplinary
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Science
Science (multidisciplinary)
Skin
Skin cancer
Species
Stem cell transplantation
Stem cells
Stem Cells - metabolism
Swine
Transgenic mice
Wound healing
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Summary:Hair follicle stem cells are key for driving growth and homeostasis of the hair follicle niche, have remarkable regenerative capacity throughout hair cycling, and display fate plasticity during cutaneous wound healing. Due to the need for a transgenic reporter, essentially all observations related to LGR5-expressing hair follicle stem cells have been generated using transgenic mice, which have significant differences in anatomy and physiology from the human. Using a transgenic pig model, a widely accepted model for human skin and human skin repair, we demonstrate that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development. We also report the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species. This information is important for understanding the fundamental differences and similarities across species, and ultimately improving human hair follicle regeneration, cutaneous wound healing, and skin cancer treatment.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-13056-w