The Role of Gaseous Molecules in Traumatic Brain Injury: An Updated Review

Traumatic brain injury (TBI) affects millions of people in China each year. TBI has a high mortality and often times a serious prognosis. The causative mechanisms of TBI during development and recovery from an injury remain vague, leaving challenges for the medical community to provide treatment opt...

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Bibliographic Details
Published in:Frontiers in neuroscience 2018-06, Vol.12, p.392-392
Main Authors: Che, Xiaoru, Fang, Yuanjian, Si, Xiaoli, Wang, Jianfeng, Hu, Xiaoming, Reis, Cesar, Chen, Sheng
Format: Article
Language:English
Subjects:
Apoptosis
Carbon monoxide
Central nervous system
gaseous molecules
Gases
Hospitals
Hydrogen
Hydrogen sulfide
Mammals
Neuroprotection
Neuroscience
Neurosurgery
Nitric oxide
Oxidative stress
Physiology
Preventive medicine
Prognosis
Therapeutic applications
Trauma
Traumatic brain injury
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Summary:Traumatic brain injury (TBI) affects millions of people in China each year. TBI has a high mortality and often times a serious prognosis. The causative mechanisms of TBI during development and recovery from an injury remain vague, leaving challenges for the medical community to provide treatment options that improve prognosis and provide an optimal recovery. Biological gaseous molecules including nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and molecular hydrogen (H ) have been found to play critical roles in physiological and pathological conditions in mammals. Accumulating evidence has found that these gaseous molecules can execute neuroprotection in many central nervous system (CNS) conditions due to their highly permeable properties allowing them to enter the brain. Considering the complicated mechanisms and the serious prognosis of TBI, effective and adequate therapeutic approaches are urgently needed. These four gaseous molecules can be potential attractive therapeutic intervention on TBI. In this review, we will present a comprehensive overview on the role of these four biological gasses in the development of TBI and their potential therapeutic applications.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2018.00392