Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-12, Vol.17 (12), p.2044-2044
Main Authors: Cardoso, Claudia R L, Salles, Gil F
Format: Article
Language:English
Subjects:
arterial stiffness
Arteries - physiopathology
Cardiovascular disease
carotid-femoral pulse wave velocity
Coronary vessels
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Female
Humans
Hypertension
Male
microvascular and macrovascular complications
Pulse Wave Analysis
Review
type 2 diabetes
Vascular Stiffness - physiology
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Summary:Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17122044