CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches

This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma applanatum, a valuable medicinal fungus used in multiple disorders belongs to Ganodermataceae family. Two extracts of G. applanatum were prepared using distilled wa...

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Bibliographic Details
Published in:Biochemistry and biophysics reports 2021-09, Vol.27, p.101062-101062, Article 101062
Main Authors: Hossen, S M Moazzem, Islam, Mohammad Jahedul, Hossain, Md. Rabiul, Barua, Anik, Uddin, Md. Giash, Emon, Nazim Uddin
Format: Article
Language:English
Subjects:
Analgesic
Anxiolytic
CNS depressant
Ganoderma applanatum
Ganodermataceae
Receptors
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Summary:This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma applanatum, a valuable medicinal fungus used in multiple disorders belongs to Ganodermataceae family. Two extracts of G. applanatum were prepared using distilled water and ethanol as solvents and named AEGA and EEGA. Open field method, rotarod method, tail suspension method, and hole cross method were utilized for the CNS depressant action. In contrast, elevated plus-maze test and hole board method were utilized for the anxiolytic action. For determining the analgesic potential, acetic acid-induced writhing test, hot plate method, and tail immersion test were used. Besides, molecular docking has been implemented by using Discovery studio 2020, UCSF Chimera and PyRx autodock vina. At both doses (200 and 400 mg/kg) of AEGA and EEGA showed significant CNS depressant effect (p 
ISSN:2405-5808
2405-5808
DOI:10.1016/j.bbrep.2021.101062