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Selective inhibition of small-diameter axons using infrared light
Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively and reve...
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| Published in: | Scientific reports 2017-06, Vol.7 (1), p.3275-8, Article 3275 |
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| creator | Lothet, Emilie H. Shaw, Kendrick M. Lu, Hui Zhuo, Junqi Wang, Yves T. Gu, Shi Stolz, Donna B. Jansen, E. Duco Horn, Charles C. Chiel, Hillel J. Jenkins, Michael W. |
| description | Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively and reversibly inhibit small-diameter axons at lower radiant exposures than large-diameter axons. We provide a mathematical rationale, and then demonstrate it experimentally in individual axons of identified neurons in the marine mollusk
Aplysia californica
, and in axons within the vagus nerve of a mammal, the musk shrew
Suncus murinus
. The ability to selectively, rapidly, and reversibly control small-diameter sensory fibers may have many applications, both for the analysis of physiology, and for treating diseases of the peripheral nervous system, such as chronic nausea, vomiting, pain, and hypertension. Moreover, the mathematical analysis of how IR affects the nerve could apply to other techniques for controlling peripheral nerve signaling. |
| doi_str_mv | 10.1038/s41598-017-03374-9 |
| format | article |
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Aplysia californica
, and in axons within the vagus nerve of a mammal, the musk shrew
Suncus murinus
. The ability to selectively, rapidly, and reversibly control small-diameter sensory fibers may have many applications, both for the analysis of physiology, and for treating diseases of the peripheral nervous system, such as chronic nausea, vomiting, pain, and hypertension. Moreover, the mathematical analysis of how IR affects the nerve could apply to other techniques for controlling peripheral nerve signaling.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-03374-9</identifier><identifier>PMID: 28607402</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378 ; 639/624 ; Animals ; Aplysia ; Axon guidance ; Axons - physiology ; Axons - radiation effects ; Electrophysiological Phenomena - radiation effects ; Humanities and Social Sciences ; Hypertension ; Infrared Rays - adverse effects ; Male ; Medical treatment ; Mollusks ; multidisciplinary ; Nausea ; Nervous system ; Neurons - physiology ; Neurons - radiation effects ; Pain ; Peripheral nerves ; Science ; Science (multidisciplinary) ; Sensory neurons ; Shellfish ; Synaptic Transmission - radiation effects ; Vagus Nerve ; Vomiting</subject><ispartof>Scientific reports, 2017-06, Vol.7 (1), p.3275-8, Article 3275</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jun 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-728f43097fabf6add60a8a599359a113c805bea418e6ab917307ed10e8d7df4f3</citedby><cites>FETCH-LOGICAL-c540t-728f43097fabf6add60a8a599359a113c805bea418e6ab917307ed10e8d7df4f3</cites><orcidid>0000-0002-5587-3912 ; 0000-0002-1750-8500</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1955562316/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1955562316?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28607402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lothet, Emilie H.</creatorcontrib><creatorcontrib>Shaw, Kendrick M.</creatorcontrib><creatorcontrib>Lu, Hui</creatorcontrib><creatorcontrib>Zhuo, Junqi</creatorcontrib><creatorcontrib>Wang, Yves T.</creatorcontrib><creatorcontrib>Gu, Shi</creatorcontrib><creatorcontrib>Stolz, Donna B.</creatorcontrib><creatorcontrib>Jansen, E. Duco</creatorcontrib><creatorcontrib>Horn, Charles C.</creatorcontrib><creatorcontrib>Chiel, Hillel J.</creatorcontrib><creatorcontrib>Jenkins, Michael W.</creatorcontrib><title>Selective inhibition of small-diameter axons using infrared light</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively and reversibly inhibit small-diameter axons at lower radiant exposures than large-diameter axons. We provide a mathematical rationale, and then demonstrate it experimentally in individual axons of identified neurons in the marine mollusk
Aplysia californica
, and in axons within the vagus nerve of a mammal, the musk shrew
Suncus murinus
. The ability to selectively, rapidly, and reversibly control small-diameter sensory fibers may have many applications, both for the analysis of physiology, and for treating diseases of the peripheral nervous system, such as chronic nausea, vomiting, pain, and hypertension. 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Duco</au><au>Horn, Charles C.</au><au>Chiel, Hillel J.</au><au>Jenkins, Michael W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective inhibition of small-diameter axons using infrared light</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-06-12</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>3275</spage><epage>8</epage><pages>3275-8</pages><artnum>3275</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively and reversibly inhibit small-diameter axons at lower radiant exposures than large-diameter axons. We provide a mathematical rationale, and then demonstrate it experimentally in individual axons of identified neurons in the marine mollusk
Aplysia californica
, and in axons within the vagus nerve of a mammal, the musk shrew
Suncus murinus
. The ability to selectively, rapidly, and reversibly control small-diameter sensory fibers may have many applications, both for the analysis of physiology, and for treating diseases of the peripheral nervous system, such as chronic nausea, vomiting, pain, and hypertension. Moreover, the mathematical analysis of how IR affects the nerve could apply to other techniques for controlling peripheral nerve signaling.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28607402</pmid><doi>10.1038/s41598-017-03374-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5587-3912</orcidid><orcidid>https://orcid.org/0000-0002-1750-8500</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378 639/624 Animals Aplysia Axon guidance Axons - physiology Axons - radiation effects Electrophysiological Phenomena - radiation effects Humanities and Social Sciences Hypertension Infrared Rays - adverse effects Male Medical treatment Mollusks multidisciplinary Nausea Nervous system Neurons - physiology Neurons - radiation effects Pain Peripheral nerves Science Science (multidisciplinary) Sensory neurons Shellfish Synaptic Transmission - radiation effects Vagus Nerve Vomiting |
| title | Selective inhibition of small-diameter axons using infrared light |
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