Validation of Angiostrongylus cantonensis combined with herpes simplex virus type 1 in cerebrospinal fluid by next-generation sequencing

[...]he was transferred to the center hospital, where the serum HSV-1 IgM was found positive and antiviral drugs were administrated. Examination for autoimmune encephalitis-related antibodies, including anti-N-methyl-D-aspartate receptor, aquaporin 4, myelin oligodendrocyte glycoprotein, and glial f...

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Bibliographic Details
Published in:Chinese medical journal 2020-01, Vol.133 (2), p.247-249
Main Authors: Zhang, Yong-Fang, Wang, Sheng-Nan, Wang, Dong-Mei, Huang, Kai-Bin, Hu, Ya-Fang
Format: Article
Language:English
Subjects:
Angiostrongylus cantonensis - pathogenicity
Animals
Antibodies
Blood-brain barrier
Cerebrospinal Fluid - parasitology
Cerebrospinal Fluid - virology
Consciousness
Correspondence
Herpes viruses
Herpesvirus 1, Human - pathogenicity
High-Throughput Nucleotide Sequencing - methods
Humans
Infections
Magnetic resonance imaging
Male
Meningitis
Middle Aged
Nervous system
Pathogens
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Summary:[...]he was transferred to the center hospital, where the serum HSV-1 IgM was found positive and antiviral drugs were administrated. Examination for autoimmune encephalitis-related antibodies, including anti-N-methyl-D-aspartate receptor, aquaporin 4, myelin oligodendrocyte glycoprotein, and glial fibrillary acidic protein antibodies in serum and CSF were all negative. Matrix metallopeptidase 9 is a protease that degrades extracellular matrix proteins and deteriorates blood-brain barrier.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000000588