Tumor Microenvironment-Responsive Drug Delivery Based on Polymeric Micelles for Precision Cancer Therapy: Strategies and Prospects

In clinical practice, drug therapy for cancer is still limited by its inefficiency and high toxicity. For precision therapy, various drug delivery systems, including polymeric micelles self-assembled from amphiphilic polymeric materials, have been developed to achieve tumor-targeting drug delivery....

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Bibliographic Details
Published in:Biomedicines 2024-02, Vol.12 (2), p.417
Main Authors: Jin, Zhu, Al Amili, Majdi, Guo, Shengrong
Format: Article
Language:English
Subjects:
Antitumor activity
Biocompatibility
Biodistribution
Blood vessels
Cancer
Cancer therapies
cancer therapy
Development and progression
Drug delivery
Drug delivery systems
Drug development
Drug therapy
Drugs
Environmental effects
Enzymes
Fatalities
Gene therapy
Growth factors
Health aspects
Hypoxia
Immunotherapy
Metastasis
Micelles
Nanoparticles
Particle size
Peptides
Permeability
Pharmacokinetics
Physiological aspects
Physiology
precision
Reactive oxygen species
stimuli-responsiveness
Therapeutic targets
Toxicity
Tumor microenvironment
Tumors
Vehicles
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Summary:In clinical practice, drug therapy for cancer is still limited by its inefficiency and high toxicity. For precision therapy, various drug delivery systems, including polymeric micelles self-assembled from amphiphilic polymeric materials, have been developed to achieve tumor-targeting drug delivery. Considering the characteristics of the pathophysiological environment at the drug target site, the design, synthesis, or modification of environmentally responsive polymeric materials has become a crucial strategy for drug-targeted delivery. In comparison to the normal physiological environment, tumors possess a unique microenvironment, characterized by a low pH, high reactive oxygen species concentration, hypoxia, and distinct enzyme systems, providing various stimuli for the environmentally responsive design of polymeric micelles. Polymeric micelles with tumor microenvironment (TME)-responsive characteristics have shown significant improvement in precision therapy for cancer treatment. This review mainly outlines the most promising strategies available for exploiting the tumor microenvironment to construct internal stimulus-responsive drug delivery micelles that target tumors and achieve enhanced antitumor efficacy. In addition, the prospects of TME-responsive polymeric micelles for gene therapy and immunotherapy, the most popular current cancer treatments, are also discussed. TME-responsive drug delivery via polymeric micelles will be an efficient and robust approach for developing clinical cancer therapies in the future.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12020417