Prognosis of remaining fetus in twin pregnancy after demise of one fetus according to its location

• Published in: BMC pregnancy and childbirth 2024-06, Vol.24 (1), p.430-9
• Main Authors: Jung, Young Mi, Park, Sun Min, Kim, Hyun Ji, Choi, Bo Young, Won, Seunghyun, Park, Jee Yoon, Oh, Kyung Joon
• Format: Article
• Language: English
• Subjects: Abortion; Adult; Anemia; Brain damage; Diabetes; Female; Fetal Death; Fetal demise; Fetus - diagnostic imaging; Fetuses; Gestational Age; Hemorrhage; Humans; Hypertension; Infant, Newborn; Magnetic resonance imaging; Medical prognosis; Pregnancy; Pregnancy complications; Pregnancy Outcome - epidemiology; Pregnancy Trimester, First; Pregnancy, Twin; Premature Birth; Preterm birth; Prognosis; Respiratory distress syndrome; Retrospective Studies; Sepsis; Stillbirth; Survival analysis; Twin pregnancy; Twins; Ultrasonography, Prenatal
• ISSN: 1471-2393; 1471-2393
• DOI: 10.1186/s12884-024-06621-w

To investigate the prognosis of the remaining fetus in twin pregnancy after experiencing one fetal demise in the first trimester according to the location of the demised fetus. This was a retrospective study of twin pregnancies with one fetal demise after the first trimester (14 weeks of gestation) delivered between September 2004 and September 2022. The study population was divided into two groups based on the location of the demised fetus as determined by the last recorded ultrasonography results: Group 1 included twin pregnancies where the presenting fetus was demised (n = 36) and Group 2 included twin pregnancies where the non-presenting fetus was demised (n = 44). The obstetric and neonatal outcomes were also reviewed. A total of 80 pregnant women were included. The median gestational age for the diagnosis of fetal demise was 24.1 weeks. The gestational age of the demised fetus was not different between Groups 1 and 2; however, the gestational age of the remaining fetus at delivery was significantly earlier in Group 1 than it was in Group 2 (33.8 vs. 37.3 weeks, P = .004). The rate of preterm birth before 28 weeks was almost five times higher in Group 1 than in Group 2 (22.2% vs. 4.5%, P = .037). Regression analysis demonstrated significant differences between Groups 1 and 2. Respiratory distress syndrome, bronchopulmonary dysplasia, patent ductus arteriosus, retinopathy of prematurity, and jaundice were more common in Group 1 than in Group 2; however, the association was not significant after adjusting for gestational age at delivery. When the presenting fetus is demised in a twin pregnancy, the remaining fetus tends to be delivered earlier than when the non-presenting fetus is demised.