ETS Transcription Factors in Immune Cells and Immune-Related Diseases

• Published in: International journal of molecular sciences 2024-09, Vol.25 (18), p.10004
• Main Authors: Yang, Yaxu, Han, Xue, Sun, Lijun, Shao, Fangyu, Yin, Yue, Zhang, Weizhen
• Format: Article
• Language: English
• Subjects: Amino acids; Animals; Autoimmune Diseases - immunology; Autoimmune Diseases - metabolism; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Binding sites; Cell cycle; Cytokines; Dendritic Cells - immunology; Dendritic Cells - metabolism; Development and progression; DNA methylation; ETS family; ETV5; Gene expression; Genetic aspects; Health aspects; Humans; immune cell; Immune system; Immune System Diseases - immunology; Immune System Diseases - metabolism; immune-related diseases; Immunoglobulins; Immunologic diseases; Kinases; Lymphocytes; Macrophages - immunology; Macrophages - metabolism; Neoplasms - immunology; Neoplasms - metabolism; Pathogens; Phosphatase; Physiological aspects; Preferences; Proto-Oncogene Proteins c-ets - genetics; Proto-Oncogene Proteins c-ets - metabolism; PU.1; Review; Roles; T cell receptors; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; transcription factor; Transcription factors
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms251810004

The development, differentiation, and function of immune cells are precisely regulated by transcription factors. The E26 transformation-specific (ETS) transcription factor family is involved in various physiological and pathological processes by regulating cell proliferation, differentiation, and apoptosis. Emerging evidence has suggested that ETS family proteins are intimately involved in the development and function of immune cells. This review summarizes the role of the ETS family in immune cells and immune-related disorders. Seven transcription factors within the ETS family, including PU.1, ETV5, ETV6, ETS1/2, ELK3, and ELF1, play essential roles in the development and function of T cells, B cells, macrophages, neutrophils, and dendritic cells. Furthermore, they are involved in the occurrence and development of immune-related diseases, including tumors, allergies, autoimmune diseases, and arteriosclerosis. This review is conducive to a comprehensive overview of the role of the ETS family in immune cells, and thus is informative for the development of novel therapeutic strategies targeting the ETS family for immune-related diseases.