Preclinical Studies of the Antimicrobial and Wound-Healing Effects of the High-Intensity Optical Irradiation “Zarnitsa-A” Apparatus

• Published in: Applied sciences 2023-09, Vol.13 (19), p.10794
• Main Authors: Bagrov, Valery V, Bukhtiyarov, Igor V, Volodin, Lev Y, Zibarev, Evgeny V, Kamrukov, Alexander S, Kondratiev, Andrey V, Krylov, Vladimir I, Nikonova, Sofya M, Novikov, Dmitry O, Semenov, Kirill A
• Format: Article
• Language: English
• Subjects: Analysis; Antibiotics; bactericidal effect; Care and treatment; Dosimetry; Drug dosages; Energy; Gram-positive bacteria; high-intensity broadband optical irradiation; Infectious diseases; Inflammatory diseases; Laboratory animals; Lamps; Methicillin; Microorganisms; Multidrug resistant organisms; Pathogens; phototherapy device; preclinical studies; pulsed xenon lamp; R&D; Research & development; Staphylococcus infections; Ultraviolet radiation; Wound healing; Wounds and injuries
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app131910794

In this paper, a new approach to treating infected wounds is proposed. It is based on treating the wound surface with high-intensity pulsed optical radiation with a continuous spectrum, continuously covering the entire UV range (from 200 to 400 nm) and the visible and near-infrared regions of the spectrum. A pulsed xenon lamp is used as a radiation source. A description of the design and technical characteristics of the device, “Zarnitsa-A”, is presented, implementing the proposed medical technology for wound therapy. The results of our studies of the apparatus in vitro and in vivo are also presented. The article shows that exposure to the apparatus leads to pronounced bactericidal- and wound-healing properties. The apparatus’s action reliably provides higher rates of wound healing compared with only a typical antibacterial or wound healing agent, such as “levomekol” ointment.