Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study

Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an i...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-04, Vol.11 (5), p.617
Main Authors: de la Rubia Ortí, Jose Enrique, Platero, Jose Luis, Benlloch, María, Franco-Martinez, Lorena, Tvarijonaviciute, Asta, Escribá-Alepuz, Jesús, Sancho-Castillo, Sandra
Format: Article
Language:English
Subjects:
beta-hydroxybutyrate
Blood
Diet
Disease
Epigallocatechin gallate
Epigallocatechin-3-gallate
Haptoglobin
Hemoglobin
Interleukin 6
Laboratories
Multiple sclerosis
muscle
Musculoskeletal system
Neuromuscular diseases
Patients
Population
Proteins
Statistical analysis
Substance abuse treatment
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Summary:Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. After 4 months of intervention with 27 MS patients, we observed that Hp does not significantly increase, alongside a significant decrease in IL-6 and a significant increase in muscle percentage. At the same time, Hp synthesis is considerably and positively correlated with IL-6 both before and after treatment; while this correlation occurs significantly reversed with muscle percentage before treatment, no correlation is evident after the intervention. These results seem to indicate that Hp could be a marker of muscle status and could be a diagnosis tool after therapeutic intervention in MS patients.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom11050617