The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported th...

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Published in:Nutrients 2024-01, Vol.16 (3), p.341
Main Authors: Hernández-Díazcouder, Adrián, Romero-Nava, Rodrigo, Del-Río-Navarro, Blanca E., Sánchez-Muñoz, Fausto, Guzmán-Martín, Carlos A., Reyes-Noriega, Nayely, Rodríguez-Cortés, Octavio, Leija-Martínez, José J., Vélez-Reséndiz, Juan Manuel, Villafaña, Santiago, Hong, Enrique, Huang, Fengyang
Format: Article
Language:English
Subjects:
Airway management
Asthma
Cytokines
Disease
Inflammation
MicroRNAs
Mortality
Plasma
Vitamin D
vitamin D3 supplementation
Vitamin deficiency
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Summary:Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported that hypovitaminosis D is frequent in patients with asthma and is associated with worsening the disease and that supplementation with vitamin D3 improves asthma symptoms. However, despite several advances in the field, the molecular mechanisms of asthma have yet to be comprehensively understood. MicroRNAs play an important role in controlling several biological processes and their deregulation is implicated in diverse diseases, including asthma. Evidence supports that the dysregulation of miR-21, miR-27b, miR-145, miR-146a, and miR-155 leads to disbalance of Th1/Th2 cells, inflammation, and airway remodeling, resulting in exacerbation of asthma. This review addresses how these molecular mechanisms explain the development of asthma and its exacerbation and how vitamin D3 may modulate these microRNAs to improve asthma symptoms.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16030341