Control of blood pressure in the cold: differentiation of skin and skeletal muscle vascular resistance

New Findings What is the central question of this study? Why does blood pressure increases during cold air exposure? Specifically, what is the contribution of skin and skeletal muscle vascular resistance during whole body versus isolated face cooling? What is the main finding and its importance? Who...

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Bibliographic Details
Published in:Experimental physiology 2023-01, Vol.108 (1), p.38-49
Main Authors: Mugele, Hendrik, Marume, Kyohei, Amin, Sachin B., Possnig, Carmen, Kühn, Lucie C., Riehl, Lydia, Pieper, Robin, Schabbehard, Eva‐Lotte, Oliver, Samuel J., Gagnon, Daniel, Lawley, Justin S.
Format: Article
Language:English
Subjects:
Air temperature
Arm
Blood Pressure
Cold
Cold Temperature
Cooling
cutaneous resistance
face cooling
Femur
Forearm
forearm vascular resistance
Humans
leg vascular resistance
Muscle, Skeletal
Musculoskeletal system
Regional Blood Flow - physiology
Skeletal muscle
Skin - blood supply
Skin Temperature
Vascular Resistance
Vasoconstriction
Vasoconstriction - physiology
whole‐body cooling
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Summary:New Findings What is the central question of this study? Why does blood pressure increases during cold air exposure? Specifically, what is the contribution of skin and skeletal muscle vascular resistance during whole body versus isolated face cooling? What is the main finding and its importance? Whole‐body cooling caused an increase in blood pressure through an increase in skeletal muscle and cutaneous vascular resistance. However, isolated mild face cooling caused an increase in blood pressure predominately via an increase in cutaneous vasoconstriction. The primary aim of this investigation was to determine the individual contribution of the cutaneous and skeletal muscle circulations to the cold‐induced pressor response. To address this, we examined local vascular resistances in the cutaneous and skeletal muscle of the arm and leg. Thirty‐four healthy individuals underwent three different protocols, whereby cold air to clamp skin temperature (27°C) was passed over (1) the whole‐body, (2) the whole‐body, but with the forearm pre‐cooled to clamp cutaneous vascular resistance, and (3) the face. Cold exposure applied to the whole body or isolated to the face increased mean arterial pressure (all, P 
ISSN:0958-0670
1469-445X
DOI:10.1113/EP090563