Current Biomaterials for Wound Healing

Wound healing is the body's process of injury recovery. Skin healing is divided into four distinct overlapping phases: hemostasis, inflammation, proliferation, and remodeling. Cell-to-cell interactions mediated by both cytokines and chemokines are imperative for the transition between these pha...

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Bibliographic Details
Published in:Bioengineering (Basel) 2023-11, Vol.10 (12), p.1378
Main Authors: Downer, Mauricio, Berry, Charlotte E, Parker, Jennifer B, Kameni, Lionel, Griffin, Michelle
Format: Article
Language:English
Subjects:
Analysis
Bioengineering
Biomaterials
Biomedical materials
Cell growth
Cell interactions
Cellulose
Chemokines
Collagen
Fibroblasts
Forecasts and trends
Growth factors
Hemostasis
Hemostatics
Homeostasis
Keratin
Mechanical properties
Methods
Nanoparticles
Plastic surgery
Polyesters
Polylactic acid
Polymers
Regeneration
Scaffolds
Skin
Skin & tissue grafts
skin repair
Tissue engineering
Vascularization
Wound healing
wound repair
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Summary:Wound healing is the body's process of injury recovery. Skin healing is divided into four distinct overlapping phases: hemostasis, inflammation, proliferation, and remodeling. Cell-to-cell interactions mediated by both cytokines and chemokines are imperative for the transition between these phases. Patients can face difficulties in the healing process due to the wound being too large, decreased vascularization, infection, or additional burdens of a systemic illness. The field of tissue engineering has been investigating biomaterials as an alternative for skin regeneration. Biomaterials used for wound healing may be natural, synthetic, or a combination of both. Once a specific biomaterial is selected, it acts as a scaffold for skin regeneration. When the scaffold is applied to a wound, it allows for the upregulation of distinct molecular signaling pathways important for skin repair. Although tissue engineering has made great progress, more research is needed in order to support the use of biomaterials for wound healing for clinical translation.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering10121378