Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding

We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost....

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Bibliographic Details
Published in:Micromachines (Basel) 2017-11, Vol.8 (11), p.328
Main Authors: Martínez Vázquez, Rebeca, Trotta, Gianluca, Volpe, Annalisa, Bernava, Giuseppe, Basile, Vito, Paturzo, Melania, Ferraro, Pietro, Ancona, Antonio, Fassi, Irene, Osellame, Roberto
Format: Article
Language:English
Subjects:
Beads
Biological effects
cell phone
femtosecond laser micromachining
Fluorescence
fluorescent cytometry
Injection molding
Lab-on-a-chip
Laser machining
Low cost
Mass production
micro-injection-molding
Micromachining
Portable equipment
Rapid prototyping
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Summary:We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi8110328