In vivo and in vitro evaluation of pharmacological activities of Adenia trilobata (Roxb.)

Adenia trilobata, locally known as akandaphal in Bangladesh, has some traditional uses. Leaves and stems extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS), which was subjected to qualitative phytochemical analysis. The qualitative phytochemical analysis of four ex...

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Bibliographic Details
Published in:Biochemistry and biophysics reports 2020-09, Vol.23, p.100772, Article 100772
Main Authors: Barua, Niloy, Ibn Aziz, Md Arfin, Tareq, Abu Montakim, Sayeed, Mohammed Aktar, Alam, Najmul, Alam, Nobi ul, Uddin, Mohammad Amran, Lyzu, Chadni, Emran, Talha Bin
Format: Article
Language:English
Subjects:
A. trilobata
Analgesic activity
Antidiarrheal
Antioxidant
Cytotoxic
Thrombolytic
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Summary:Adenia trilobata, locally known as akandaphal in Bangladesh, has some traditional uses. Leaves and stems extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS), which was subjected to qualitative phytochemical analysis. The qualitative phytochemical analysis of four extracts showed the presence of secondary metabolites such as alkaloid, carbohydrate, glycosides, flavonoids, phenols, flavonol, and saponins. All four extracts of A. trilobata, exhibited a strong antioxidant activity while a moderately (MEATS = 328 μg/mL) to weakly toxic (NFATL = 616.85 μg/mL) LC50 observed in brine shrimp lethality bioassay. In thrombolytic test, MEATL (18.54 ± 2.18%; P 
ISSN:2405-5808
2405-5808
DOI:10.1016/j.bbrep.2020.100772