Evaluating bioactive constituents and toxicological effects of aqueous extract of fermented Pentaclethra macrophylla seeds in rats

This study aimed at evaluating the bioactive constituents and the toxicological profile of the aqueous fermented seed extract of . The chemical constituents of fermented were assessed using GC-MS. For acute toxicity study, one-time doses of up to 5000 mg/kg of the extract were orally administered to...

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Bibliographic Details
Published in:Avicenna journal of phytomedicine 2020-01, Vol.10 (1), p.101-113
Main Authors: Ugbogu, Eziuche Amadike, Nwoku, Chukwumaobim Daniel, Ude, Victor Chibueze, Emmanuel, Okezie
Format: Article
Language:English
Subjects:
bioactive compounds
hepatic enzyme
histopathology
lipid profile
Original
pentaclethra macrophylla
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Summary:This study aimed at evaluating the bioactive constituents and the toxicological profile of the aqueous fermented seed extract of . The chemical constituents of fermented were assessed using GC-MS. For acute toxicity study, one-time doses of up to 5000 mg/kg of the extract were orally administered to male and female rats whereas 200, 400 and 800 mg/kg of the extract were orally administered daily for 14 days in sub-acute toxicity investigation. Biochemical, haematological and lipid profiles were assessed following standard methods. Bioactive compounds such as citronellol and oxirane, tetradecyl- (hexadecylene oxide) were identified in the extract. In acute toxicity test, no death or sign of toxicity was identified. For sub-acute study, ALT decreased significantly (p
ISSN:2228-7930
2228-7949
DOI:10.22038/AJP.2019.13557