MicroRNA-653-5p Promotes Gastric Cancer Proliferation and Metastasis by Targeting the SOCS6-STAT3 Pathway

MicroRNAs (miRNAs) are emerging as significant regulators of the tumorigenesis of gastric cancer (GC), and may be effective biomarkers for diagnosis, prognosis, and therapeutic targeting for GC. In this study, miR-653-5p was found to be significantly upregulated in GC tissues, serum, and cell lines...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2021-04, Vol.8, p.655580-655580
Main Authors: Li, Zengliang, Fan, Hao, Chen, Wangwang, Xiao, Jian, Ma, Xiang, Ni, Peidong, Xu, Zekuan, Yang, Li
Format: Article
Language:English
Subjects:
cancer prognosis
gastric cancer
JAK2/STAT3 pathway
miR-653-5p
Molecular Biosciences
SOCS6
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Summary:MicroRNAs (miRNAs) are emerging as significant regulators of the tumorigenesis of gastric cancer (GC), and may be effective biomarkers for diagnosis, prognosis, and therapeutic targeting for GC. In this study, miR-653-5p was found to be significantly upregulated in GC tissues, serum, and cell lines and was strongly associated with poor prognosis in patients with GC. Furthermore, miR-653-5p promoted GC cell proliferation and metastasis and . Suppressor of cytokine signaling 6 (SOCS6) was directly targeted by miR-653-5p, and SOCS6 attenuated miR-653-5p-mediated GC cell growth, migration, and invasion. In addition, SOCS6-mediated inactivation of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway was also reversed by the administration of miR-653-5p. The findings from this study support a novel regulatory axis between miR-653-5p, SOCS6, and JAK2/STAT3 that may be a target for diagnosis and therapeutic intervention for GC.
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2021.655580