High-Sensitivity C-reactive Protein and Tumor Necrosis Factor Alpha in Pseudoexfoliation Syndrome

• Published in: Oman medical journal 2013, Vol.28 (1), p.15-19
• Main Authors: Ghorbanihaghjo , Amir, Sorkhabi , Rana, Ahoor , Mohamadhossein
• Format: Article
• Language: English
• Subjects: ASCORBIC ACID; DYSFUNCTION; ENDOTHELIAL CELLS; EYE DISEASES; High sensitivity C-reactive protein; INFLAMMATION; IRAN; Original; PATHOPHYSIOLOGY; Pseudoexfoliation syndrome; SENSITIVITY; SYSTEMIC DISEASES; Tumor necrosis factor alpha; أمراض العين; إيران; الأمراض الجهازية; الإلتهاب; الحساسية; الخلايا البطانية; الخلل الوظيفي; الفسيولوجيا المرضية; حمض الأسكوربيك
• ISSN: 1999-768X; 2070-5204
• DOI: 10.5001/omj.2013.04

The purpose of the present study was to determine the alterations in high-sensitivity C-reactive protein and Tumor Necrosis factor alpha levels in the blood serum of pseudoexfoliation syndrome cases (a disease with similar risk factors as systemic endothelial dysfunction diseases) and to compare the results with healthy individuals. High-sensitivity C-reactive protein and Tumor Necrosis factor alpha levels were determined in 30 cases with pseudoexfoliation syndrome and in 30 control patients of the same age and sex, by enzyme-linked immunosorbent assay. The levels of high- sensitivity C-reactive protein and Tumor Necrosis factor alpha in the blood serum of patients with pseudoexfoliation syndrome (3.95±0.88 mg/l, 3.32±0.99 pg/ml, respectively) were significantly higher than in the control group (2.51±0.79mg/l, 0.43±0.15 pg/ml, respectively) p=0.001, p=0.002. The results suggest that increased levels of high- sensitivity C-reactive protein and Tumor Necrosis factor alpha, as markers of inflammation and peripheral endothelial dysfunction in pseudoexfoliation syndrome, may be risk factors for systemic and ocular manifestations of pseudoexfoliation syndrome.