Case Report: Angiomatoid fibrous histiocytoma in the hand: a rare clinical presentation and diagnostic challenge

Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of mesenchymal origin occurring in young adults. Based on its clinical course, it is said to have an intermediate potential. We present a case of a 59-year-old woman with AFH in the hand that was difficult to diagnose. A benign soft tissue tumor...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology 2023-12, Vol.13, p.1280630
Main Authors: Ichikawa, Jiro, Kawasaki, Tomonori, Imada, Hiroki, Wako, Masanori, Fujimaki, Taro, Tatsuno, Rikito, Jubashi, Takahiro, Haro, Hirotaka
Format: Article
Language:English
Subjects:
angiomatoid fibrous histiocytoma
clinical presentation
differential diagnosis
histopathology
magnetic resonance imaging
Oncology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of mesenchymal origin occurring in young adults. Based on its clinical course, it is said to have an intermediate potential. We present a case of a 59-year-old woman with AFH in the hand that was difficult to diagnose. A benign soft tissue tumor was suspected on magnetic resonance imaging, and its size and open biopsy suggested nodular fasciitis or inflammatory myofibroblastic tumor. A diagnosis of AFH was eventually made based on the analysis of the resected specimens. The characteristic findings of histopathology and immunohistochemistry in this case were relatively poor, so fluorescence hybridization contributed to making the correct diagnosis. Considering its prognosis, careful follow-up was decided upon without additional surgery. Our case is a challenging one because of its atypical presentation and inconclusive imaging and histopathological findings.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1280630