Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles

Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients,...

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Published in:Frontiers in cardiovascular medicine 2018-01, Vol.5, p.2-2
Main Authors: van der Vorst, Emiel P C, de Jong, Renske J, Donners, Marjo M P C
Format: Article
Language:English
Subjects:
atherosclerosis
Cardiovascular Medicine
challenges
extracellular vesicles
proteolytic activity
vascular inflammation
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description Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.
doi_str_mv 10.3389/fcvm.2018.00002
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subjects atherosclerosis
Cardiovascular Medicine
challenges
extracellular vesicles
proteolytic activity
vascular inflammation
title Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles
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