Association between systemic immune inflammation Index and all-cause mortality in incident peritoneal dialysis-treated CKD patients: a multi-center retrospective cohort study

• Published in: BMC nephrology 2024-01, Vol.25 (1), p.8-8, Article 8
• Main Authors: Tang, Ruiying, Chen, Jiexin, Zhou, Qian, Deng, Jihong, Zhan, Xiaojiang, Wang, Xiaoyang, Wen, Yueqiang, Su, Ning, Feng, Xiaoran, Xu, Qingdong
• Format: Article
• Language: English
• Subjects: All-cause mortality; Analysis; Care and treatment; Cerebrovascular disease; Chronic kidney failure; Cohort analysis; Comorbidity; Computer simulation; Continuous ambulatory peritoneal dialysis; Creatinine; Diabetes; Diagnosis; Health risk assessment; Hemodialysis; Hospitals; Humans; Hypertension; Inflammation; Inflammation - etiology; Inflammatory diseases; Kidney diseases; Lymphocytes; Malnutrition; Medical prognosis; Medical research; Medicine, Experimental; Methods; Mortality; Neutrophils; Normal distribution; Patient outcomes; Peritoneal dialysis; Peritoneal Dialysis - adverse effects; Peritoneum; Population; Prevention; Prognosis; Proportional Hazards Models; Proteins; Regression analysis; Renal Insufficiency, Chronic - etiology; Retrospective Studies; Risk assessment; Risk factors; Software; Systemic immune inflammation index
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-023-03451-4

Chronic inflammatory disorders in peritoneal dialysis (PD) contribute to the adverse clinical outcome. Systemic immune inflammation index (SII) is the novel and convenient measurement that is positively associated with various diseases. However, scarce is known regarding the association between SII with all-cause mortality among PD patients. In this multi-center retrospective cohort study, 1,677 incident patients with PD were enrolled. Eligible patients were stratified into groups based on SII level: tertile 1( 819.03). The primary endpoint was the all-cause mortality. Both Cox regression analysis and competing risk models were used to examine the association between SII and all-cause mortality. Subgroup analysis was performed to assess the influence of the SII tertiles on all-cause mortality in different subgroups. During the follow-up period of 30.5 ± 20.0 months, 26.0% (437/1,677) patients died, of whom the SII tertile 3 group accounted for 39.1% (171/437) of the deaths. Patients in the SII tertile 3 group had a higher all-cause mortality rate than patients in the SII tertile 1 and 2 groups (log-rank = 13.037, P