A multidisciplinary approach to an uncommon case of laryngeal leishmaniasis in Turkey

Leishmaniasis is a zoonotic disease caused by the genus Leishmania. A sandfly vector called Phlebotomus is the agent responsible for transmitting the pathogen to humans. The disease may be found in 1 of 3 forms, visceral leishmaniasis (VL), cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasi...

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Bibliographic Details
Published in:Journal of vector borne diseases 2014-06, Vol.51 (2), p.140-143
Main Authors: Gökmen, Tülin Güven, Haytoglu, Süheyl, Güran, Mümtaz, Kusçu, Ferit, Köksal, Fatih
Format: Article
Language:English
Subjects:
Aged, 80 and over
Amphotericin B - pharmacology
Biopsy
Care and treatment
Case studies
Deoxyribonucleic acid
Diagnosis
DNA
DNA Primers - genetics
DNA sequencing
Giemsa
laryngeal leishmaniasis
miniexon
Humans
Infections
Laryngeal diseases
Laryngeal Diseases - drug therapy
Laryngeal Diseases - parasitology
Larynx
Leishmania infantum - genetics
Leishmaniasis, Cutaneous
Leishmaniasis, Mucocutaneous - drug therapy
Leishmaniasis, Mucocutaneous - parasitology
Leishmaniasis, Mucocutaneous - pathology
Male
Methods
Patients
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Risk factors
Sequence Analysis, DNA
Tomography, X-Ray Computed
Treatment Outcome
Turkey
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Summary:Leishmaniasis is a zoonotic disease caused by the genus Leishmania. A sandfly vector called Phlebotomus is the agent responsible for transmitting the pathogen to humans. The disease may be found in 1 of 3 forms, visceral leishmaniasis (VL), cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (ML), depending mainly on the infecting species and the host immune response. Leishmaniasis is endemic in 88 countries, particularly localized in areas of the tropics, subtropics, and southern Europe. In most of the ML cases, the nasal cavity is affected, but the localization of Leishmania spp in the laryngeal mucosa is unusual. Furthermore, laryngeal mucosa involvement can appear in patients with previous CL as well as being part of a widespread VL in immuno-supressed patients who suffer infections beyond the mononuclear phagocyte system. Here we report a rare case of treated laryngeal ML due to Leishmania infantum in an 81-yr old male patient resident of Adana, Turkey which is a subtropical area. The case was investigated with a multidisciplinary approach.
ISSN:0972-9062
0972-9062
DOI:10.4103/0972-9062.134825