Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis

Background. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A sys...

Full description

Saved in:
Bibliographic Details
Published in:Gastroenterology research and practice 2017-01, Vol.2017 (2017), p.1-15
Main Authors: Yu, Tao, Cheng, Di, Huang, Can-Ze, Xu, Ji-Hao, Wu, Ting-Feng, Li, Jie-Yao, Li, Jun-Zhen, Chen, Qi-Kui
Format: Article
Language:English
Subjects:
Bacteria
Bias
Clinical medicine
Complications and side effects
Diabetes
Endocrinology
Gastroenterology
Health risk assessment
Helicobacter infections
Infections
Insulin
Meta-analysis
Pediatrics
Review
Risk factors
Software
Studies
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c566t-bd72a6d6c16fd5fb98fa5ee9da9c809a13c14b2e5b4f1c45c65e72b10f89a4403
cites cdi_FETCH-LOGICAL-c566t-bd72a6d6c16fd5fb98fa5ee9da9c809a13c14b2e5b4f1c45c65e72b10f89a4403
container_end_page 15
container_issue 2017
container_start_page 1
container_title Gastroenterology research and practice
container_volume 2017
creator Yu, Tao
Cheng, Di
Huang, Can-Ze
Xu, Ji-Hao
Wu, Ting-Feng
Li, Jie-Yao
Li, Jun-Zhen
Chen, Qi-Kui
description Background. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results. 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P
doi_str_mv 10.1155/2017/5715403
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_f039dfa1de1f4f3aa02d71e64cbc8f56</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A536987535</galeid><doaj_id>oai_doaj_org_article_f039dfa1de1f4f3aa02d71e64cbc8f56</doaj_id><sourcerecordid>A536987535</sourcerecordid><originalsourceid>FETCH-LOGICAL-c566t-bd72a6d6c16fd5fb98fa5ee9da9c809a13c14b2e5b4f1c45c65e72b10f89a4403</originalsourceid><addsrcrecordid>eNqNks1vEzEQxVcIREvhxhmtxAWJpvWs114vB6SofDRSgUsrcbNm7XHiarNO1xuq_Pc4H00J4oB8sPX8mzfy-GXZa2BnAEKcFwyqc1GBKBl_kh2DVNVIcvbz6cMZCjjKXsR4y5gsGBPPs6NCKcUVh-MsXFLrTWjQDNTni1Ubep9POkdm8KHLJzEfxxiMx4Fsfu-HWX69WlBe5J88NjRQPM2_h2Erwl78kI-7_GZhN1XfaMDRuMN2FX18mT1z2EZ6tdtPspsvn68vLkdXP75OLsZXIyOkHEaNrQqUVhqQzgrX1MqhIKot1kaxGoEbKJuCRFM6MKUwUlBVNMCcqrFMkzjJJltfG_BWL3o_x36lA3q9EUI_1dgP3rSkHeO1dQiWwJWOI7LCVkCyNI1RTsjk9XHrtVg2c7KGuqHH9sD08KbzMz0Nv7QQVSG5SAbvdgZ9uFtSHPTcR0Ntix2FZdRQ80qAEgAJffsXehuWfRrehioqDrVgj9QU0wN850Lqa9ameiy4rFUlNm3P_kGlZWme_rwj55N-UHC6LTB9iLEnt38jML0Om16HTe_ClvA3f85lDz-kKwHvt8DMdxbv_X_aUWLI4SMNQpYK-G_D7-Sj</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932731950</pqid></control><display><type>article</type><title>Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis</title><source>PubMed Central (Open Access)</source><source>Wiley-Blackwell Open Access Collection</source><source>Publicly Available Content Database</source><creator>Yu, Tao ; Cheng, Di ; Huang, Can-Ze ; Xu, Ji-Hao ; Wu, Ting-Feng ; Li, Jie-Yao ; Li, Jun-Zhen ; Chen, Qi-Kui</creator><contributor>Enck, Paul</contributor><creatorcontrib>Yu, Tao ; Cheng, Di ; Huang, Can-Ze ; Xu, Ji-Hao ; Wu, Ting-Feng ; Li, Jie-Yao ; Li, Jun-Zhen ; Chen, Qi-Kui ; Enck, Paul</creatorcontrib><description>Background. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results. 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P&lt;0.001). The difference was significant in comparison between type 2 DM group and non-DM group (OR = 2.05), but not in that between type 1 DM group and non-DM group (OR = 1.23, 95% CI: 0.77–1.96, P=0.38). Conclusion. Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. And the difference is associated with type 2 DM but not type 1 DM.</description><identifier>ISSN: 1687-6121</identifier><identifier>EISSN: 1687-630X</identifier><identifier>DOI: 10.1155/2017/5715403</identifier><identifier>PMID: 28883831</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Bacteria ; Bias ; Clinical medicine ; Complications and side effects ; Diabetes ; Endocrinology ; Gastroenterology ; Health risk assessment ; Helicobacter infections ; Infections ; Insulin ; Meta-analysis ; Pediatrics ; Review ; Risk factors ; Software ; Studies ; Type 2 diabetes</subject><ispartof>Gastroenterology research and practice, 2017-01, Vol.2017 (2017), p.1-15</ispartof><rights>Copyright © 2017 Jun-Zhen Li et al.</rights><rights>COPYRIGHT 2017 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2017 Jun-Zhen Li et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Jun-Zhen Li et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-bd72a6d6c16fd5fb98fa5ee9da9c809a13c14b2e5b4f1c45c65e72b10f89a4403</citedby><cites>FETCH-LOGICAL-c566t-bd72a6d6c16fd5fb98fa5ee9da9c809a13c14b2e5b4f1c45c65e72b10f89a4403</cites><orcidid>0000-0003-4939-8956 ; 0000-0001-9523-6873</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1932731950/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1932731950?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28883831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Enck, Paul</contributor><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Cheng, Di</creatorcontrib><creatorcontrib>Huang, Can-Ze</creatorcontrib><creatorcontrib>Xu, Ji-Hao</creatorcontrib><creatorcontrib>Wu, Ting-Feng</creatorcontrib><creatorcontrib>Li, Jie-Yao</creatorcontrib><creatorcontrib>Li, Jun-Zhen</creatorcontrib><creatorcontrib>Chen, Qi-Kui</creatorcontrib><title>Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis</title><title>Gastroenterology research and practice</title><addtitle>Gastroenterol Res Pract</addtitle><description>Background. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results. 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P&lt;0.001). The difference was significant in comparison between type 2 DM group and non-DM group (OR = 2.05), but not in that between type 1 DM group and non-DM group (OR = 1.23, 95% CI: 0.77–1.96, P=0.38). Conclusion. Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. And the difference is associated with type 2 DM but not type 1 DM.</description><subject>Bacteria</subject><subject>Bias</subject><subject>Clinical medicine</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Gastroenterology</subject><subject>Health risk assessment</subject><subject>Helicobacter infections</subject><subject>Infections</subject><subject>Insulin</subject><subject>Meta-analysis</subject><subject>Pediatrics</subject><subject>Review</subject><subject>Risk factors</subject><subject>Software</subject><subject>Studies</subject><subject>Type 2 diabetes</subject><issn>1687-6121</issn><issn>1687-630X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNks1vEzEQxVcIREvhxhmtxAWJpvWs114vB6SofDRSgUsrcbNm7XHiarNO1xuq_Pc4H00J4oB8sPX8mzfy-GXZa2BnAEKcFwyqc1GBKBl_kh2DVNVIcvbz6cMZCjjKXsR4y5gsGBPPs6NCKcUVh-MsXFLrTWjQDNTni1Ubep9POkdm8KHLJzEfxxiMx4Fsfu-HWX69WlBe5J88NjRQPM2_h2Erwl78kI-7_GZhN1XfaMDRuMN2FX18mT1z2EZ6tdtPspsvn68vLkdXP75OLsZXIyOkHEaNrQqUVhqQzgrX1MqhIKot1kaxGoEbKJuCRFM6MKUwUlBVNMCcqrFMkzjJJltfG_BWL3o_x36lA3q9EUI_1dgP3rSkHeO1dQiWwJWOI7LCVkCyNI1RTsjk9XHrtVg2c7KGuqHH9sD08KbzMz0Nv7QQVSG5SAbvdgZ9uFtSHPTcR0Ntix2FZdRQ80qAEgAJffsXehuWfRrehioqDrVgj9QU0wN850Lqa9ameiy4rFUlNm3P_kGlZWme_rwj55N-UHC6LTB9iLEnt38jML0Om16HTe_ClvA3f85lDz-kKwHvt8DMdxbv_X_aUWLI4SMNQpYK-G_D7-Sj</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Yu, Tao</creator><creator>Cheng, Di</creator><creator>Huang, Can-Ze</creator><creator>Xu, Ji-Hao</creator><creator>Wu, Ting-Feng</creator><creator>Li, Jie-Yao</creator><creator>Li, Jun-Zhen</creator><creator>Chen, Qi-Kui</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4939-8956</orcidid><orcidid>https://orcid.org/0000-0001-9523-6873</orcidid></search><sort><creationdate>20170101</creationdate><title>Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis</title><author>Yu, Tao ; Cheng, Di ; Huang, Can-Ze ; Xu, Ji-Hao ; Wu, Ting-Feng ; Li, Jie-Yao ; Li, Jun-Zhen ; Chen, Qi-Kui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-bd72a6d6c16fd5fb98fa5ee9da9c809a13c14b2e5b4f1c45c65e72b10f89a4403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bacteria</topic><topic>Bias</topic><topic>Clinical medicine</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Gastroenterology</topic><topic>Health risk assessment</topic><topic>Helicobacter infections</topic><topic>Infections</topic><topic>Insulin</topic><topic>Meta-analysis</topic><topic>Pediatrics</topic><topic>Review</topic><topic>Risk factors</topic><topic>Software</topic><topic>Studies</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Cheng, Di</creatorcontrib><creatorcontrib>Huang, Can-Ze</creatorcontrib><creatorcontrib>Xu, Ji-Hao</creatorcontrib><creatorcontrib>Wu, Ting-Feng</creatorcontrib><creatorcontrib>Li, Jie-Yao</creatorcontrib><creatorcontrib>Li, Jun-Zhen</creatorcontrib><creatorcontrib>Chen, Qi-Kui</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gastroenterology research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Tao</au><au>Cheng, Di</au><au>Huang, Can-Ze</au><au>Xu, Ji-Hao</au><au>Wu, Ting-Feng</au><au>Li, Jie-Yao</au><au>Li, Jun-Zhen</au><au>Chen, Qi-Kui</au><au>Enck, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis</atitle><jtitle>Gastroenterology research and practice</jtitle><addtitle>Gastroenterol Res Pract</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>1687-6121</issn><eissn>1687-630X</eissn><abstract>Background. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods. A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results. 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P&lt;0.001). The difference was significant in comparison between type 2 DM group and non-DM group (OR = 2.05), but not in that between type 1 DM group and non-DM group (OR = 1.23, 95% CI: 0.77–1.96, P=0.38). Conclusion. Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. And the difference is associated with type 2 DM but not type 1 DM.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28883831</pmid><doi>10.1155/2017/5715403</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-4939-8956</orcidid><orcidid>https://orcid.org/0000-0001-9523-6873</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1687-6121
ispartof Gastroenterology research and practice, 2017-01, Vol.2017 (2017), p.1-15
issn 1687-6121
1687-630X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_f039dfa1de1f4f3aa02d71e64cbc8f56
source PubMed Central (Open Access); Wiley-Blackwell Open Access Collection; Publicly Available Content Database
subjects Bacteria
Bias
Clinical medicine
Complications and side effects
Diabetes
Endocrinology
Gastroenterology
Health risk assessment
Helicobacter infections
Infections
Insulin
Meta-analysis
Pediatrics
Review
Risk factors
Software
Studies
Type 2 diabetes
title Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T21%3A04%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Helicobacter%20pylori%20Infection%20Is%20Associated%20with%20Type%202%20Diabetes,%20Not%20Type%201%20Diabetes:%20An%20Updated%20Meta-Analysis&rft.jtitle=Gastroenterology%20research%20and%20practice&rft.au=Yu,%20Tao&rft.date=2017-01-01&rft.volume=2017&rft.issue=2017&rft.spage=1&rft.epage=15&rft.pages=1-15&rft.issn=1687-6121&rft.eissn=1687-630X&rft_id=info:doi/10.1155/2017/5715403&rft_dat=%3Cgale_doaj_%3EA536987535%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c566t-bd72a6d6c16fd5fb98fa5ee9da9c809a13c14b2e5b4f1c45c65e72b10f89a4403%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1932731950&rft_id=info:pmid/28883831&rft_galeid=A536987535&rfr_iscdi=true