Development and application of rTMS device to murine model

Repetitive transcranial magnetic stimulation (rTMS) is attracting attention as a new treatment technique for brain lesions, and many animal studies showing its effects have been reported. However, the findings of animal application researches cannot directly represent the effects of rTMS in human, m...

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Bibliographic Details
Published in:Scientific reports 2023-04, Vol.13 (1), p.5490-5490, Article 5490
Main Authors: Choung, Jin Seung, Bhattacharjee, Sohom, Son, Jeong Pyo, Kim, Jong Moon, Cho, Dong Sik, Cho, Choon Sik, Kim, MinYoung
Format: Article
Language:English
Subjects:
631/114/116/2392
639/166/985
Alzheimer's disease
Animal models
Animals
Brain research
Computer Simulation
Design
Disease Models, Animal
Electric fields
Head
Humanities and Social Sciences
Humans
Magnetic Fields
Magnetic resonance imaging
Mice
multidisciplinary
Rodents
Science
Science (multidisciplinary)
Simulation
Transcranial magnetic stimulation
Transcranial Magnetic Stimulation - methods
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Summary:Repetitive transcranial magnetic stimulation (rTMS) is attracting attention as a new treatment technique for brain lesions, and many animal studies showing its effects have been reported. However, the findings of animal application researches cannot directly represent the effects of rTMS in human, mainly due to size difference and mechanistic characteristics of rTMS. Therefore, the authors purposed to develop a mouse rTMS to simulate clinical application and to confirm. Firstly, a virtual head model was created according to magnetic resonance images of murine head. Then, simulations of rTMS stimulation with different coils were performed on the murine head phantom, and an rTMS device for mice was fabricated based on the optimal voltage conditions. Lastly, strengths of magnetic fields generated by the two rTMS devices, for human (conventional clinical use) and mouse (newly fabricated), were measured in air and on mouse head and compared. Resultantly, the magnetic field intensity generated by coil of mouse was lower than human’s ( p   0.05). Further in vivo researches using miniaturized rTMS devices for murine head should be followed to be more meaningful for human.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-32646-w