Changes and significance of vascular endothelial injury markers in patients with diabetes mellitus and pulmonary thromboembolism

To investigate the changes and clinical significance of vascular endothelial injury markers in type 2 diabetes mellitus (T2DM) complicated with pulmonary embolism (PE). This prospective study enrolled patients with T2DM hospitalized in one hospital from January 2021 to June 2022. Soluble thrombomodu...

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Bibliographic Details
Published in:BMC pulmonary medicine 2023-05, Vol.23 (1), p.183-10, Article 183
Main Authors: Li, Fan, Yuan, Lianfang, Shao, Na, Yang, Xiaokun, Yang, Shaohua, He, Linjia, Ding, Jie, Ding, Ming, Yang, Shengzhe, Fu, Wenwen, Wang, Congcong, Li, Xiaochen, Cai, Qiling
Format: Article
Language:English
Subjects:
Analysis
Angiography
Atherosclerosis
Biomarkers
Cardiovascular disease
Care and treatment
Cholesterol
Circulating endothelial cells
Computed tomography
Coronary vessels
Correlation analysis
Creatinine
CT imaging
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetics
Embolism
Endothelial Cells
Endothelium, Vascular - chemistry
Enzyme-linked immunosorbent assay
Flow cytometry
Glucose
Hemoglobin
High density lipoprotein
Hospitals
Humans
Hypertension
Laboratories
Lungs
Methods
Patients
Plasma
Plasma levels
Prevention
Prospective Studies
Pulmonary arteries
Pulmonary Embolism
Pulmonary embolisms
Pulmonology
Risk factors
Soluble thrombomodulin
Statistical analysis
Stroke
Thromboembolism
Vascular endothelial injury
Vein & artery diseases
Von Willebrand factor
von Willebrand Factor - analysis
Weight control
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Summary:To investigate the changes and clinical significance of vascular endothelial injury markers in type 2 diabetes mellitus (T2DM) complicated with pulmonary embolism (PE). This prospective study enrolled patients with T2DM hospitalized in one hospital from January 2021 to June 2022. Soluble thrombomodulin (sTM) (ELISA), von Willebrand factor (vWF) (ELISA), and circulating endothelial cells (CECs) (flow cytometry) were measured. PE was diagnosed by computed tomography pulmonary angiography (CTPA). Thirty participants were enrolled in each group. The plasma levels of sTM (151.22 ± 120.57 vs. 532.93 ± 243.82 vs. 1016.51 ± 218.00 pg/mL, P 
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-023-02486-5