Hyperacute Graft-Versus-Host Disease of the Skin following Allogeneic Stem Cell Transplantation: A Paediatric Case Series

• Published in: Indian journal of dermatology 2023-01, Vol.68 (1), p.73-77
• Main Authors: Mahabal, Gauri D, George, Leni, Peter, Dincy, Thomas, Meera, George, Biju, Mathews, Vikram, Abraham, Aby, Srivastava, Alok, Pulimood, Susanne
• Format: Article
• Language: English
• Subjects: Complications and side effects; Graft versus host disease; Hematopoietic stem cells; hyperacute gvhd; Liver; Mortality; paediatric transplantation; Pediatrics; Risk factors; Short Communication; Skin; Skin diseases; Stem cell transplantation; Stem cells; Steroids; Transplantation
• ISSN: 0019-5154; 1998-3611
• DOI: 10.4103/ijd.ijd_503_22

Hyperacute GVHD (HaGVHD) is a rare complication of hematopoietic stem cell transplantation (HSCT) occurring before engraftment, a syndrome commonly involving skin and/or gut and/or liver, with increased morbidity and mortality. Myeloablative conditioning (MAC) regimes and mismatched donor transplants have an increased risk for HaGVHD. There is a higher chance of steroid-refractoriness and chronic GVHD in those who develop HaGVHD. There is limited literature about HaGVHD, especially in the paediatric age group. This retrospective single-centre case series included five paediatric patients who underwent HSCT between 1 April 2013 and 31 July 2015 at a tertiary care centre in South India, who fulfilled the criteria for HaGVHD as per criteria by Kim . and whose follow up data was available. We noted their risk factors, clinical course and prognosis. There were five paediatric HaGVHD patients. The risk factors noted among them were MAC regimen in three and mismatched unrelated donor sources in three. Two had steroid-refractory disease, four went on to develop chronic GVHD and three died of GVHD or treatment-related complications. A high index of suspicion is necessary to recognize HaGVHD, especially in patients with known risk factors developing a fever with rash post-HSCT.