Advances in the Total Synthesis of Aflatoxins

Aflatoxins, which are produced by , , and , are a group of pentacyclic natural products with difuran and coumarin skeletons. They mainly include aflatoxin B , B , G , G , M , and M . Biologically, aflatoxins are of concern to human health as they can be present as contaminants in food products. The...

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Bibliographic Details
Published in:Frontiers in chemistry 2021-11, Vol.9, p.779765-779765
Main Authors: Yang, Liyan, Wang, Zhonglei
Format: Article
Language:English
Subjects:
aflatoxins
Chemistry
contaminants
formal syntheses
natural products
total syntheses
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Summary:Aflatoxins, which are produced by , , and , are a group of pentacyclic natural products with difuran and coumarin skeletons. They mainly include aflatoxin B , B , G , G , M , and M . Biologically, aflatoxins are of concern to human health as they can be present as contaminants in food products. The unique skeletons of aflatoxins and their risk to human health have led to the publication of nine remarkable total syntheses (including three asymmetric syntheses) and ten formal total syntheses (including four asymmetric formal syntheses) of aflatoxins in the past 55 years. To better understand the mechanism of the biological activity of aflatoxins and their presence in samples from the food industry, this review summarizes progress in the total synthesis of aflatoxins.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.779765