Pharmaceuticals in Coastal Waters: An UHPLC-TOF-MS Multi-Residue Approach

Anthropogenic chemical contamination represents a key stressor of natural environments with pharmaceuticals comprising a particular group of emerging pollutants with the potential to induce biological responses in non-target organisms. Therefore, an analytical method based on ultra-high-performance...

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Bibliographic Details
Published in:Applied sciences 2023-05, Vol.13 (10), p.5975
Main Authors: Leston, Sara, Freitas, Andreia, Rosa, João, Vila Pouca, Ana Sofia, Barbosa, Jorge, Reis-Santos, Patrick, Fonseca, Vanessa F, Pardal, Miguel A, Ramos, Fernando
Format: Article
Language:English
Subjects:
Acids
Amoxicillin
Analgesics
Annual reports
Anthropogenic factors
Antibiotics
Anticonvulsants
Antidepressants
Antihypertensive drugs
Antihypertensives
Chemical contamination
Chemical pollution
Chromatography
Ciprofloxacin
Coastal waters
Contamination
drugs
Ecosystems
emerging contaminants
environmental contamination
Estuaries
Health aspects
High performance liquid chromatography
Ions
Legislation
Lipids
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Natural environment
Nonsteroidal anti-inflammatory drugs
Nontarget organisms
Ofloxacin
Oxytetracycline
Pharmaceuticals
Pollutants
Residues
Scientific imaging
seawater
Solvents
Sulfamethoxazole
Surface water
Surveillance
Trimethoprim
UHPLC-TOF-MS
Venlafaxine
Water treatment
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Summary:Anthropogenic chemical contamination represents a key stressor of natural environments with pharmaceuticals comprising a particular group of emerging pollutants with the potential to induce biological responses in non-target organisms. Therefore, an analytical method based on ultra-high-performance liquid chromatography coupled to time-of-flight tandem mass spectrometry (UHPLC-TOF-MS) was developed for estuarine and seawaters, targeting 63 globally used pharmaceuticals (including amoxicillin, ciprofloxacin, sulfamethoxazole, trimethoprim and venlafaxine included in the Surface Water Watch List) from 8 therapeutic groups: antibiotics, analgesic, NSAIDs, antidepressants, β-blockers, lipid regulators, anticonvulsants and antihypertensive drugs. The method presents high selectivity and sensitivity, with the limits of detection ranging from 0.01 to 8.92 ng/L and the limits of quantification from 0.02 to 29.73 ng/L. Considering precision, the highest value was achieved for amoxicillin (20.9%) and the lower for ofloxacin (2.6%), while recoveries ranged from 80.6 to 112.6%. Overall, the quantification method was highly efficient for multi-residues quantification in such complex environmental samples.
ISSN:2076-3417
2076-3417
DOI:10.3390/app13105975